Evidence map›Paper›PMID 20651746›Full record

ReviewNature reviews. Immunology2010

The X chromosome in immune functions: when a chromosome makes the difference.

Claude Libert, Lien Dejager, Iris Pinheiro

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 430 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
430citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

430 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. The extra X chromosome and autoimmune susceptibility in Klinefelter syndrome.The Journal of clinical endocrinology and metabolism · 2026
    Pooled it
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  4. Turner Syndrome and the Thyroid Function-A Systematic and Critical Review.International journal of molecular sciences · 2024
    Pooled it
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  13. A Genetic Risk Variant Associated With the Risk of Primary Biliary Cholangitis Is Inherited From Neanderthals.Liver international : official journal of the International Association for the Study of the Liver · 2026
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370 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Claude LibertDepartment for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), 9052 Ghent, Belgium. Claude.Libert@dmbr.vib-ugent.be
Lien Dejager
Iris Pinheiro

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In response to various immune challenges, females show better survival than males; the X chromosome has an important role in this immunological advantage. X chromosome-linked diseases are usually restricted to males, who have only one copy of the X chromosome; however, females are more prone to autoimmune diseases, and the X chromosome may be involved in the breakdown of self tolerance. Several hypotheses have been proposed in recent years that support a role for the X chromosome in shaping autoimmune responses. Here, we review the main mechanisms responsible for increased immune activity in females. This provides a survival advantage in the face of pathogenic insult but can also enhance the susceptibility of females to autoimmunity.

Indexed as

Adaptive ImmunityAutoimmune DiseasesChromosomes, Human, XCommunicable DiseasesDisease SusceptibilityFemaleHumansMaleSex Factors

Identifiers

PMID20651746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.