ArticleJournal of endocrinological investigation2011
Cornea in acromegalic patients as a possible target of growth hormone action.
Article in Journal of endocrinological investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Growth hormone therapy and ocular biometry in paediatric growth hormone deficiency: a systematic review and meta-analysis.Eye (London, England) · 2026Pooled it
- Lens densitometry alterations in acromegaly: Quantitative insights from Scheimpflug imaging and hormonal correlation.Indian journal of ophthalmology · 2026Observational
- Evaluation of static and dynamic pupil responses in patients with acromegaly with automatic pupillometer.BMC ophthalmology · 2026Article
- Impact of GH and IGF-I excess on nervous and vascular retinal structure in newly diagnosed acromegaly patients.Pituitary · 2025Article
- Intraocular Pressure (IOP) in Patients with Acromegaly versus Healthy Controls: A Systematic Review and Meta-Analysis.Vision (Basel, Switzerland) · 2024Review
- Corneal Tonometric and Morphological Changes in Patients with Acromegaly.Journal of clinical medicine · 2022Article
- Sex Hormones, Growth Hormone, and the Cornea.Cells · 2022Review
- Choroidal thickness measurements in children with isolated growth hormone deficiency.Eye (London, England) · 2018Article
- Retina ganglion cell/inner plexiform layer and peripapillary nerve fiber layer thickness in patients with acromegaly.International ophthalmology · 2017Article
- Differential Effects of Hormones on Cellular Metabolism in Keratoconus In Vitro.Scientific reports · 2017Article
- Comparing two acromegalic patients with respect to central corneal thickness, intraocular pressure, and tear insulin-like growth factor levels before and after treatment.Indian journal of ophthalmology · 2015Article
- Novel Therapy to Treat Corneal Epithelial Defects: A Hypothesis with Growth Hormone.The ocular surface · 2015Review
- Article
- Ocular findings in Sheehan's syndrome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Evaluation of central corneal and central retinal thicknesses and intraocular pressure in acromegaly patients.Pituitary · 2014Article
- Comparing acromegalic patients to healthy controls with respect to intraocular pressure, central corneal thickness, and optic disc topography findings.Indian journal of ophthalmology · 2014Article
- Corneal biomechanical properties measured by the ocular response analyzer in acromegalic patients.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Article
- Elevated intraocular pressure in patients with acromegaly.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Observational
- Corneal properties in children with congenital isolated growth hormone deficiency.International journal of ophthalmology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGH exerts its effects on many organs and the eye also seems to be a target site, although few authors have investigated the corneal thickness in patients with acromegaly.
aimTo perform a detailed ophthalmological evaluation in acromegalic patients, in relation to disease activity. MATERIAL AND
methodsTwenty-eight acromegalic patients (11 males, 17 females) and 22 voluntary healthy subjects underwent complete metabolic and ophthalmological evaluation, including retinal thickness (RT), central corneal thickness (CCT), and intraocular pressure values (IOP).
resultsSignificantly greater CCT values were found in all acromegalic patients in comparison with controls (567 vs 528.5 μm; p<0.001), without concomitant greater corrected IOP. No difference was found for RT. Analyzing these data according to disease activity, uncontrolled patients showed greater CCT values (573.5 vs 559 μm; p=0.002) and corrected IOP (17.4 vs 16 mmHg; p=0.001) than the controlled ones. CCT also correlated with basal and nadir GH after oral glucose load levels, IGF-I levels, and duration of active disease.
conclusionsAcromegaly is characterized by greater CCT values, supporting the hypothesis that GH excess may have stimulatory effects on the cornea as well as on other target organs. Higher GH levels, disease control status and duration of active disease seem to be the main causes of increased corneal thickness. We suggest a careful and detailed corneal evaluation in acromegalic patients to prevent the potential risk of increased IOP, in addition to the already-known complications.
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