Evidence map›Paper›PMID 20651163›Full record

ArticleJournal of the American Society of Nephrology : JASN2010

Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosis.

Tahira P Alves, Xuelei Wang, Jackson T Wright, Lawrence J Appel, Tom Greene, Keith Norris, Julia Lewis, AASK Collaborative Research Group

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 50 citations in OpenAlex.

  1. Arteriosclerosis, thrombosis, and vascular biology · 2017
    Trial
  2. Impact of Educational Attainment on Health Outcomes in Moderate to Severe CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Trial
  3. Review
  4. Article
  5. Article
  6. Exploring psychosocial stressors as contributors to racial disparity in end-stage renal disease.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021
    Article
  7. Observational
  8. Article
  9. Kidney Appreciates Stable Blood Pressure.American journal of hypertension · 2018
    Article
  10. Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017
    Article
  11. APOL1 Gene Kidney Risk Variants and Cardiovascular Disease: Getting to the Heart of the Matter.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017
    Review
  12. BP Control and Long-Term Risk of ESRD and Mortality.Journal of the American Society of Nephrology : JASN · 2017
    Article
  13. Article
  14. Review
  15. Observational
  16. Article
  17. Risk Factors for Rapid Kidney Function Decline Among African Americans: The Jackson Heart Study (JHS).American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Article
  18. Review
  19. Cause-Specific Deaths in Non-Dialysis-Dependent CKD.Journal of the American Society of Nephrology : JASN · 2015
    Article
  20. Estimating time to ESRD using kidney failure risk equations: results from the African American Study of Kidney Disease and Hypertension (AASK).American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015
    Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Tahira P AlvesDepartment of Medicine, Division of Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. tahira.palmer@yahoo.com
Xuelei Wang
Jackson T Wright
Lawrence J Appel
Tom Greene
Keith Norris
Julia Lewis
AASK Collaborative Research Group
Case Western Reserve University · USCharles R. Drew University of Medicine and Science · USCleveland Clinic · USJohns Hopkins University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Utah · USVanderbilt University · US

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2010
$74.3M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
ZIPRASIDONE (GEODON) AUGMENTATION IN SEROTONIN REUPTAKE INHIBITOR-RESISTANT OBM01RR000071 · NCRR · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI NEWCORN, JEFFREY H · 1985 to 2009
$41.5M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
YQ MICRODELETIONS AND MALE INFERTILITYP20RR011145 · NCRR · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI NORRIS, KEITH C · 1995 to 2009
$17.0M
WARCEFP20RR011104 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI MENG, YUAN-XIANG · 1995 to 2009
$14.5M
MENTORING PROGRAM FOR CLINICAL RESEARCHERS IN NEPHROLOGYK24DK002818 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2001 to 2010
$1.5M
NCRR NIH HHS 2P20 RR11104NCRR NIH HHS 5M01 RR-00071NCRR NIH HHS M01 RR000052NCRR NIH HHS M01 RR000071NCRR NIH HHS M01 RR00052NCRR NIH HHS M01 RR000827NCRR NIH HHS M01 RR00827NCRR NIH HHS P20 RR011104NCRR NIH HHS P20 RR011145NCRR NIH HHS P20-RR11145NCRR NIH HHS UL1 RR024989NIDDK NIH HHS K24 DK002818PHS HHS M01 00032
6 · The paper itself

Abstract

In several studies, patients with CKD seemed to be at greater risk for dying from cardiovascular disease (CVD) than reaching ESRD. The purpose of this study was to compare incident ESRD rates with rates of total mortality, CVD death, and a CVD composite (CVD mortality and CVD hospitalization) among participants who had hypertensive nephrosclerosis and were enrolled in the African American Study of Kidney Disease and Hypertension (AASK). The study period included the AASK trial phase (1996 through 2001) and a subsequent cohort phase (2002 through 2007). The AASK enrolled 1094 participants. Of the 764 participants who completed the trial phase without an event, 691 (90%) enrolled in the cohort phase. During 11 years of follow-up, there were 59 CVD-related deaths and 118 non-CVD-related deaths. The rate of ESRD (3.9/100 patient-years) was significantly higher than the rates of total mortality (2.2/100 patient-years), CVD mortality (0.8/100 patient-years), and the CVD composite (3.2/100 patient-years). The incidence rate ratio of ESRD to CVD mortality was 5.0. The rate of ESRD consistently exceeded the various mortality rates across most of the subgroups defined by age, gender, income, education, previous CVD, baseline urine protein excretion, and baseline estimated GFR. In conclusion, AASK participants were more likely to reach ESRD than to die.

Indexed as

Black or African AmericanAdultAgedCardiovascular DiseasesFemaleHumansHypertensionIncidenceKidney Failure, ChronicMaleMiddle AgedNephrosclerosis

Identifiers

PMID20651163
PMCPMC2938597
OpenAlexW2146835192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.