Evidence map›Paper›PMID 20651086›Full record

ArticleBlood2010

Tissue factor mutated at the allosteric Cys186-Cys209 disulfide bond is severely impaired in decrypted procoagulant activity.

Wolfram Ruf, Henri H Versteeg

Open access · bronzeAbstract readCommentLetter
In one paragraph

Article in Blood, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Protein disulfide isomerase enhances tissue factor-dependent thrombin generation.Biochemical and biophysical research communications · 2018
    Article
  4. Article
  5. Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.Arteriosclerosis, thrombosis, and vascular biology · 2017
    Article
  6. Article
  7. Review
  8. Regulation of tissue factor coagulant activity on cell surfaces.Journal of thrombosis and haemostasis : JTH · 2012
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Tissue factor and cell signalling in cancer progression and thrombosis.Journal of thrombosis and haemostasis : JTH · 2011
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Wolfram Ruf
Henri H Versteeg
Leiden University Medical Center · NLScripps Research Institute · US

Funding

THROMBUS FORMATION IN BABOONSP01HL031950 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI GRIFFIN, JOHN H · 1985 to 2015
$29.4M
NHLBI NIH HHS HL-31950NHLBI NIH HHS P01 HL031950
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Allosteric SiteAmino Acid SubstitutionCystineDisulfidesEndothelial CellsFactor VIIaHumansIn Vitro TechniquesMutagenesis, Site-DirectedMutant ProteinsRecombinant ProteinsThromboplastinTransduction, GeneticCystineDisulfidesFactor VIIaMutant ProteinsRecombinant ProteinsThromboplastin

Identifiers

PMID20651086
PMCPMC2913451
OpenAlexW1971525594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.