Evidence map›Paper›PMID 20651019›Full record

ArticleAJNR. American journal of neuroradiology

Magnetization transfer imaging provides no evidence of demyelination in methotrexate-induced encephalopathy.

F R Miese, F R Schuster, K Pierstorff, M Karenfort, H J Laws, A Borkhardt, A Saleh

Open access · hybridAbstract readCase Reports
In one paragraph

Article in AJNR. American journal of neuroradiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

F R MieseInstitute of Radiology, Center for Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany. falk.miese@med.uni-duesseldorf.de
F R Schuster
K Pierstorff
M Karenfort
H J Laws
A Borkhardt
A Saleh
Heinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subacute MTX-induced encephalopathy is characterized by an abrupt onset of focal neurologic deficits within days after intrathecal or systemic therapy. Demyelination is one proposed mechanism. We describe the neuroimaging features of 2 patients with clinical symptoms of subacute encephalopathy after intrathecal and systemic MTX therapy. DWI showed restricted diffusion, indicating cytotoxic edema. MTI yielded no evidence of demyelination in either patient because there was no loss of MTR in areas of restricted diffusion.

Indexed as

AdolescentAntimetabolites, AntineoplasticBrainBrain DiseasesChildDemyelinating DiseasesFemaleHumansImage EnhancementMagnetic Resonance ImagingMethotrexateNeurotoxicity SyndromesAntimetabolites, AntineoplasticMethotrexate

Identifiers

PMID20651019
PMCPMC8013136
OpenAlexW2043790149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.