ArticleThe Journal of biological chemistry2010
Both forward and reverse TCA cycles operate in green sulfur bacteria.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 93 citations in OpenAlex.
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- Genome Sequence and Phylogenetic Analysis of the Sulfide-Oxidizing Heliobacterium "Microorganisms · 2026Article
- Evidence for ecological adaptation of reductive citric acid and reverse oxidative citric acid cycles based on a survey of genomes from autotrophicFEMS microbes · 2026Review
- Prebiotic formation of thioesters via cyclic anhydrides as a key step in the emergence of metabolism.Scientific reports · 2025Article
- Biological significance of sperm-independent calcium oscillations in immature oocytes of mice.microPublication biology · 2025Article
- Metabolic cross-feeding interactions modulate the dynamic community structure in microbial fuel cell under variable organic loading wastewaters.PLoS computational biology · 2024Article
- The Impact of AbovegroundMicroorganisms · 2024Article
- Anoxygenic photosynthesis with emphasis on green sulfur bacteria and a perspective for hydrogen sulfide detoxification of anoxic environments.Frontiers in microbiology · 2024Review
- Co-cultures from Plants and Cyanobacteria: A New Way for Production Systems in Agriculture and Bioprocess Engineering.Advances in biochemical engineering/biotechnology · 2024Review
- Late acquisition of the rTCA carbon fixation pathway by Chlorobi.Nature ecology & evolution · 2023Article
- Pathophysiological Effects of Contemporary Lifestyle on Evolutionary-Conserved Survival Mechanisms in Polycystic Ovary Syndrome.Life (Basel, Switzerland) · 2023Review
- Motile bacteria leverage bioconvection for eco-physiological benefits in a natural aquatic environment.Frontiers in microbiology · 2023Article
- Photoautotrophic Growth Rate Enhancement ofBiology · 2022Article
- Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis.Angewandte Chemie (International ed. in English) · 2022Article
- Extracellular Electrons Powered Microbial COAdvances in biochemical engineering/biotechnology · 2022Article
- Article
- Emerging Role of TCA Cycle-Related Enzymes in Human Diseases.International journal of molecular sciences · 2021Review
- Remarkably coherent population structure for a dominant Antarctic Chlorobium species.Microbiome · 2021Article
- TCA Cycle Replenishing Pathways in Photosynthetic Purple Non-Sulfur Bacteria Growing with Acetate.Life (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The anoxygenic green sulfur bacteria (GSBs) assimilate CO(2) autotrophically through the reductive (reverse) tricarboxylic acid (RTCA) cycle. Some organic carbon sources, such as acetate and pyruvate, can be assimilated during the phototrophic growth of the GSBs, in the presence of CO(2) or HCO(3)(-). It has not been established why the inorganic carbonis required for incorporating organic carbon for growth and how the organic carbons are assimilated. In this report, we probed carbon flux during autotrophic and mixotrophic growth of the GSB Chlorobaculum tepidum. Our data indicate the following: (a) the RTCA cycle is active during autotrophic and mixotrophic growth; (b) the flux from pyruvate to acetyl-CoA is very low and acetyl-CoA is synthesized through the RTCA cycle and acetate assimilation; (c) pyruvate is largely assimilated through the RTCA cycle; and (d) acetate can be assimilated via both of the RTCA as well as the oxidative (forward) TCA (OTCA) cycle. The OTCA cycle revealed herein may explain better cell growth during mixotrophic growth with acetate, as energy is generated through the OTCA cycle. Furthermore, the genes specific for the OTCA cycle are either absent or down-regulated during phototrophic growth, implying that the OTCA cycle is not complete, and CO(2) is required for the RTCA cycle to produce metabolites in the TCA cycle. Moreover, CO(2) is essential for assimilating acetate and pyruvate through the CO(2)-anaplerotic pathway and pyruvate synthesis from acetyl-CoA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.