ArticleThe Journal of pediatrics2010
Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants?
Article in The Journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates.
Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Risk factors for necrotizing enterocolitis in preterm infants: a Meta analysis.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Pooled it
- Stopping enteral feeds for prevention of transfusion-associated necrotising enterocolitis in preterm infants.The Cochrane database of systematic reviews · 2019Pooled it
- Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial.JAMA pediatrics · 2020Trial
- Two faces of necrotizing enterocolitis: early and late-onset disease in preterm infants.Pediatric surgery international · 2026Article
- Environmental exposures in the neonatal intensive care unit impacting neurodevelopmental outcomes for neonates.Pediatric research · 2025Review
- Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- A Detailed Protocol for the Induction of Anemia and RBC Transfusion-associated Necrotizing Enterocolitis in Neonatal Mice.Bio-protocol · 2024Article
- The effect of haemoglobin and blood transfusion on preterm infant gut perfusion and injury.Frontiers in pediatrics · 2024Article
- Retrospective cohort study of neonatal blood transfusion in China.BMC pediatrics · 2023Article
- The short-term effects of RBC transfusions on intestinal injury in preterm infants.Pediatric research · 2023Article
- Association between prognostic factors and the clinical deterioration of preterm neonates with necrotizing enterocolitis.Scientific reports · 2022Article
- Neonatal anemia relates to intestinal injury in preterm infants.Pediatric research · 2022Article
- Observational
- Early versus late-onset necrotizing enterocolitis in very low birth infants in the neonatal intensive care unit.Pediatric surgery international · 2022Article
- Association of Bolus Feeding With Splanchnic and Cerebral Oxygen Utilization Efficiency Among Premature Infants With Anemia and After Blood Transfusion.JAMA network open · 2020Article
- A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions.Nature communications · 2019Article
- Response to Dr. Nair.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Feeding during transfusion and the risk of necrotizing enterocolitis in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Epidemiology of Necrotizing Enterocolitis: New Considerations Regarding the Influence of Red Blood Cell Transfusions and Anemia.Clinics in perinatology · 2019Review
- Impact of red blood cell transfusions on intestinal barrier function in preterm infants.Journal of neonatal-perinatal medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that red blood cell (RBC) transfusions increase the risk of necrotizing enterocolitis (NEC) in premature infants, we investigated whether the risk of "transfusion-associated" NEC is higher in infants with lower hematocrits and advanced postnatal age. STUDY
designRetrospective comparison of NEC patients and control patients born at < 34 weeks gestation.
resultsThe frequency of RBC transfusions was similar in NEC patients (47/93, 51%) and control patients (52/91, 58%). Late-onset NEC (> 4 weeks of age) was more frequently associated with a history of transfusion(s) than early-onset NEC (adjusted OR, 6.7; 95% CI, 1.5 to 31.2; P = .02). Compared with nontransfused patients, RBC-transfused patients were born at earlier gestational ages, had greater intensive care needs (including at the time of onset of NEC), and longer hospital stay. A history of RBC transfusions within 48-hours before NEC onset was noted in 38% of patients, most of whom were extremely low birth weight infants.
conclusionsIn most patients, RBC transfusions were temporally unrelated to NEC and may be merely a marker of overall severity of illness. However, the relationship between RBC transfusions and NEC requires further evaluation in extremely low birth weight infants using a prospective cohort design.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.