ArticleGenomics2010
Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.
Article in Genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors.Molecular pharmacology · 2024Review
- Phosphoinositides in New Spaces.Cold Spring Harbor perspectives in biology · 2023Review
- Identification of candidate biomarkers and pathways associated with type 1 diabetes mellitus using bioinformatics analysis.Scientific reports · 2022Article
- Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors.Small GTPases · 2022Article
- Review
- Review
- The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.The Journal of biological chemistry · 2020Article
- Clinical significance of NCOA5 gene rs2903908 polymorphism in Behçet's disease.EXCLI journal · 2017Article
- PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs).The Journal of biological chemistry · 2016Article
- Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.Nature medicine · 2015Article
- DNA methylation analysis of phenotype specific stratified Indian population.Journal of translational medicine · 2015Article
- An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux.The EMBO journal · 2015Article
- Regulation and function of P-Rex family Rac-GEFs.Small GTPases · 2015Review
- NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2014Article
- Molecular mechanisms for the regulation of insulin-stimulated glucose uptake by small guanosine triphosphatases in skeletal muscle and adipocytes.International journal of molecular sciences · 2014Review
- NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet.Cell metabolism · 2014Article
- Rho GTPases in insulin-stimulated glucose uptake.Small GTPases · 2014Review
- NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma.Cancer cell · 2013Article
- Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs.American journal of human genetics · 2013Article
- Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study.Cardiovascular diabetology · 2013Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Chromosome 20q12-q13.1 has been linked to type 2 diabetes (T2D) in multiple populations. We examined the influence of genes in this region on T2D and BMI in two European American case-control populations. SNPs were genotyped in 300 diabetic patients and 310 controls. A subset of 72 SNPs were further genotyped in 470 cases and 442 controls. All genes examined showed evidence of association with T2D in the initial sample (additive P-value [P(a)]=0.00090-0.045). SNPs near PREX1 were also associated in the second case-control population (P(a)=0.017-0.042). The combined analysis resulted in the same SNPs, among others, associated with T2D (P(a)=0.0013-0.041). Stratification analysis by T2D status showed that association with BMI was observed solely in cases (P(a)=0.0018-0.041). Mediation testing revealed that 30-40% of the effects of these SNPs on T2D were significantly mediated by BMI. SNPs near PREX1 may contribute to T2D susceptibility mediated through effects of adiposity in European Americans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.