ArticleBMC medical genetics2010
FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings.Molecular psychiatry · 2020Pooled it
- Parental communication and psychosis: a meta-analysis.Schizophrenia bulletin · 2014Pooled it
- PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.Journal of molecular neuroscience : MN · 2012Pooled it
- DoesNarra J · 2024Article
- Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development.Nature neuroscience · 2023Article
- Language abnormalities in schizophrenia: binding core symptoms through contemporary empirical evidence.Schizophrenia (Heidelberg, Germany) · 2022Review
- Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular proportions and phenotypes.Molecular psychiatry · 2022Article
- The Brain Connectome for Chinese Reading.Neuroscience bulletin · 2022Review
- Sexual dimorphism in the relationship betweenFrontiers in aging neuroscience · 2022Article
- Pleiotropy between language impairment and broader behavioral disorders-an investigation of both common and rare genetic variants.Journal of neurodevelopmental disorders · 2021Article
- FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.Brain imaging and behavior · 2021Article
- The link among microbiota, epigenetics, and disease development.Environmental science and pollution research international · 2021Review
- The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia.NPJ schizophrenia · 2021Article
- The Etiology of Auditory Hallucinations in Schizophrenia: From Multidimensional Levels.Frontiers in neuroscience · 2021Review
- Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder.Journal of clinical medicine · 2020Review
- Article
- Genome-wide association study of multisite chronic pain in UK Biobank.PLoS genetics · 2019Article
- Functional characterization of two enhancers located downstream FOXP2.BMC medical genetics · 2019Article
- A Penny for Your Thoughts: Children's Inner Speech and Its Neuro-Development.Frontiers in psychology · 2019Review
- Positive and balancing selection onEvolution letters · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchizophrenia is considered a language related human specific disease. Previous studies have reported evidence of positive selection for schizophrenia-associated genes specific to the human lineage. FOXP2 shows two important features as a convincing candidate gene for schizophrenia vulnerability: FOXP2 is the first gene related to a language disorder, and it has been subject to positive selection in the human lineage.
methodsTwenty-seven SNPs of FOXP2 were genotyped in a cohort of 293 patients with schizophrenia and 340 controls. We analyzed in particular the association with the poverty of speech and the intensity of auditory hallucinations. Potential expansion of three trinucleotide repeats of FOXP2 was also screened in a subsample. Methylation analysis of a CpG island, located in the first exon of the gene, was performed in post-mortem brain samples, as well as qRT-PCR analysis.
resultsA significant association was found between the SNP rs2253478 and the item Poverty of speech of the Manchester scale (p = 0.038 after Bonferroni correction). In patients, we detected higher degree of methylation in the left parahippocampus gyrus than in the right one.
conclusionsFOXP2 might be involved in the language disorder in patients with schizophrenia. Epigenetic factors might be also implicated in the developing of this disorder.
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