ArticleGenome biology2010
Analysis of the copy number profiles of several tumor samples from the same patient reveals the successive steps in tumorigenesis.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 108 citations in OpenAlex.
- ChromoPattern: characterizing chromosomal rearrangement patterns of copy number alteration in heterogeneous tumor cell populations at single-cell resolution.Briefings in bioinformatics · 2025Article
- DICE: fast and accurate distance-based reconstruction of single-cell copy number phylogenies.Life science alliance · 2025Article
- Cancer phylogenetic inference using copy number alterations detected from DNA sequencing data.Cancer pathogenesis and therapy · 2025Review
- A Novel Gene Expression Scoring System Predicts Recurrence in Non-Muscle-Invasive Bladder Cancer Patients.Cancer medicine · 2024Article
- Copy number architectures define treatment-mediated selection of lethal prostate cancer clones.Nature communications · 2023Article
- Single-cell methylation sequencing data reveal succinct metastatic migration histories and tumor progression models.Genome research · 2023Article
- CNETML: maximum likelihood inference of phylogeny from copy number profiles of multiple samples.Genome biology · 2023Article
- MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution.Genome biology · 2022Article
- Methylation subgroup and molecular heterogeneity is a hallmark of glioblastoma: implications for biopsy targeting, classification and therapy.ESMO open · 2022Article
- Joint Clustering of Single-Cell Sequencing and Fluorescence In Situ Hybridization Data for Reconstructing Clonal Heterogeneity in Cancers.Journal of computational biology : a journal of computational molecular cell biology · 2021Article
- DEVOLUTION-A method for phylogenetic reconstruction of aneuploid cancers based on multiregional genotyping data.Communications biology · 2021Article
- Article
- Clinically relevant molecular subtypes and genomic alteration-independent differentiation in gynecologic carcinosarcoma.Nature communications · 2019Article
- Article
- Comprehensive statistical inference of the clonal structure of cancer from multiple biopsies.Scientific reports · 2017Article
- A population genetics perspective on the determinants of intra-tumor heterogeneity.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Tumor evolution: Linear, branching, neutral or punctuated?Biochimica et biophysica acta. Reviews on cancer · 2017Review
- The evolution of tumour phylogenetics: principles and practice.Nature reviews. Genetics · 2017Review
- Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine.Trends in cancer · 2016Review
- From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a computational method, TuMult, for reconstructing the sequence of copy number changes driving carcinogenesis, based on the analysis of several tumor samples from the same patient. We demonstrate the reliability of the method with simulated data, and describe applications to three different cancers, showing that TuMult is a valuable tool for the establishment of clonal relationships between tumor samples and the identification of chromosome aberrations occurring at crucial steps in cancer progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.