ArticleEvolution; international journal of organic evolution2010
Rapid decline in fitness of mutation accumulation lines of gonochoristic (outcrossing) Caenorhabditis nematodes.
Article in Evolution; international journal of organic evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Conservative evolution of genetic and genomic features inbioRxiv : the preprint server for biology · 2025Article
- Germline mutation rate is elevated in young and old parents inEvolution letters · 2023Article
- Causes of variability in estimates of mutational variance from mutation accumulation experiments.Genetics · 2022Article
- Experimental Evolution withGenetics · 2017Review
- Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation.BMC biology · 2015Article
- The role of hermaphrodites in the experimental evolution of increased outcrossing rates in Caenorhabditis elegans.BMC evolutionary biology · 2014Article
- Mainstreaming Caenorhabditis elegans in experimental evolution.Proceedings. Biological sciences · 2014Review
- The genetic basis and experimental evolution of inbreeding depression in Caenorhabditis elegans.Heredity · 2014Article
- Invariance (?) of mutational parameters for relative fitness over 400 generations of mutation accumulation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2012Article
- Causes and consequences of the evolution of reproductive mode in Caenorhabditis nematodes.Trends in genetics : TIG · 2012Review
- High mutation rates in the mitochondrial genomes of Daphnia pulex.Molecular biology and evolution · 2012Article
- No evidence of elevated germline mutation accumulation under oxidative stress in Caenorhabditis elegans.Genetics · 2011Article
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6 authors.
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Abstract
Evolutionary theory predicts that the strength of natural selection to reduce the mutation rate should be stronger in self-fertilizing than in outcrossing taxa. However, the relative efficacy of selection on mutation rate relative to the many other factors influencing the evolution of any species is poorly understood. To address this question, we allowed mutations to accumulate for ∼100 generations in several sets of "mutation accumulation" (MA) lines in three species of gonochoristic (dieocious) Caenorhabditis (C. remanei, C. brenneri, C. sp. 5) as well as in a dioecious strain of the historically self-fertile hermaprohodite C. elegans. In every case, the rate of mutational decay is substantially greater in the gonochoristic taxa than in C. elegans (∼4× greater on average). Residual heterozygosity in the ancestral controls of these MA lines introduces some complications in interpreting the results, but circumstantial evidence suggests the results are not primarily due to inbreeding depression resulting from residual segregating variation. The results suggest that natural selection operates to optimize the mutation rate in Caenorhabditis and that the strength (or efficiency) of selection differs consistently on the basis of mating system, as predicted by theory. However, context-dependent environmental and/or synergistic epistasis could also explain the results.
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