Evidence map›Paper›PMID 20649473›Full record

ReviewAntioxidants & redox signaling2011

Reactive oxygen species in the regulation of synaptic plasticity and memory.

Cynthia A Massaad, Eric Klann

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants & redox signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06282965 (A Randomized, Double-blind, Placebo Controlled Study of the Safety and Efficacy of Angiotensin), which is not on this map. Cited by 320 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
320citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06282965 phase1 / phase2recruitingnot on this mapstarted 2024, after this paper: background citation

A Randomized, Double-blind, Placebo Controlled Study of the Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury (TBI)

TypeinterventionalSponsorUniversity of ArizonaRan2024 to 2027Enrolled90ConditionsTraumatic Brain InjuryArmsAngiotensin (1-7), Sterile saline
3 · Its place in the literature

Who cites it

320 citing papers in PubMed, 3 syntheses or guidelines pooled it, 616 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Reframing Alzheimer's Disease Through a Redox-Metabolic Framework.International journal of molecular sciences · 2026
    Review
  7. Article
  8. Article
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  10. Review
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  14. The therapeutic pipeline in migraine: What does the future hold?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  15. Article
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  17. Article
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  19. Review
  20. Article

260 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Cynthia A MassaadDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. cmassaad@bcm.edu
Eric Klann
Baylor College of Medicine · USNew York University · US

Funding

Reactive Oxygen Species Signaling in the HippocampusR01NS034007 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLANN, ERIC · 2000 to 2012
$4.2M
OXIDATIVE ACTIVATION OF PKC DURING INDUCTION OF LTPR29NS034007 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLANN, ERIC · 1995 to 1999
–
NINDS NIH HHS NS034007
6 · The paper itself

Abstract

The brain is a metabolically active organ exhibiting high oxygen consumption and robust production of reactive oxygen species (ROS). The large amounts of ROS are kept in check by an elaborate network of antioxidants, which sometimes fail and lead to neuronal oxidative stress. Thus, ROS are typically categorized as neurotoxic molecules and typically exert their detrimental effects via oxidation of essential macromolecules such as enzymes and cytoskeletal proteins. Most importantly, excessive ROS are associated with decreased performance in cognitive function. However, at physiological concentrations, ROS are involved in functional changes necessary for synaptic plasticity and hence, for normal cognitive function. The fine line of role reversal of ROS from good molecules to bad molecules is far from being fully understood. This review focuses on identifying the multiple sources of ROS in the mammalian nervous system and on presenting evidence for the critical and essential role of ROS in synaptic plasticity and memory. The review also shows that the inability to restrain either age- or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memory function.

Indexed as

AnimalsAntioxidantsHumansMemoryReactive Oxygen SpeciesSynapsesAntioxidantsReactive Oxygen Species

Identifiers

PMID20649473
PMCPMC3078504
OpenAlexW1986219537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.