ArticleJournal of mass spectrometry : JMS2010
Elucidating the higher-order structure of biopolymers by structural probing and mass spectrometry: MS3D.
Article in Journal of mass spectrometry : JMS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Top-Down Proteoform Analysis by 2D MS with Quadrupolar Detection.Analytical chemistry · 2023Article
- MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex.Biomolecules · 2019Article
- Bifunctional cross-linking approaches for mass spectrometry-based investigation of nucleic acids and protein-nucleic acid assemblies.Methods (San Diego, Calif.) · 2018Article
- Development of Large-scale Cross-linking Mass Spectrometry.Molecular & cellular proteomics : MCP · 2018Article
- An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Change in the Molecular Dimension of a RAGE-Ligand Complex Triggers RAGE Signaling.Structure (London, England : 1993) · 2016Article
- Monitoring Solution Structures of Peroxisome Proliferator-Activated Receptor β/δ upon Ligand Binding.PloS one · 2016Article
- xVis: a web server for the schematic visualization and interpretation of crosslink-derived spatial restraints.Nucleic acids research · 2015Article
- Automated assignment of MS/MS cleavable cross-links in protein 3D-structure analysis.Journal of the American Society for Mass Spectrometry · 2015Article
- Progress and outlook in structural biology of large viral RNAs.Virus research · 2014Review
- Reliable identification of cross-linked products in protein interaction studies by 13C-labeled p-benzoylphenylalanine.Journal of the American Society for Mass Spectrometry · 2014Article
- Structure-specific ribonucleases for MS-based elucidation of higher-order RNA structure.Journal of the American Society for Mass Spectrometry · 2014Article
- Distance restraints from crosslinking mass spectrometry: mining a molecular dynamics simulation database to evaluate lysine-lysine distances.Protein science : a publication of the Protein Society · 2014Article
- Structural analysis of guanylyl cyclase-activating protein-2 (GCAP-2) homodimer by stable isotope-labeling, chemical cross-linking, and mass spectrometry.Journal of the American Society for Mass Spectrometry · 2013Article
- Cross-linking and mass spectrometry methodologies to facilitate structural biology: finding a path through the maze.Journal of structural and functional genomics · 2013Review
- Mixed-isotope labeling with LC-IMS-MS for characterization of protein-protein interactions by chemical cross-linking.Journal of the American Society for Mass Spectrometry · 2013Article
- Article
- Modification of the zonal elution method for detection of transient protein-protein interactions involving ligand exchange.Analytical chemistry · 2012Article
- Integrating mass spectrometry of intact protein complexes into structural proteomics.Proteomics · 2012Review
Corrections and comments
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2 authors.
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Abstract
Chemical probing represents a very versatile alternative for studying the structure and dynamics of substrates that are intractable by established high-resolution techniques. The implementation of MS-based strategies for the characterization of probing products has not only extended the range of applicability to virtually all types of biopolymers but has also paved the way for the introduction of new reagents that would not have been viable with traditional analytical platforms. As the availability of probing data is steadily increasing on the wings of the development of dedicated interpretation aids, powerful computational approaches have been explored to enable the effective utilization of such information to generate valid molecular models. This combination of factors has contributed to making the possibility of obtaining actual 3D structures by MS-based technologies (MS3D) a reality. Although approaches for achieving structure determination of unknown targets or assessing the dynamics of known structures may share similar reagents and development trajectories, they clearly involve distinctive experimental strategies, analytical concerns and interpretation paradigms. This Perspective offers a commentary on methods aimed at obtaining distance constraints for the modeling of full-fledged structures while highlighting common elements, salient distinctions and complementary capabilities exhibited by methods used in dynamics studies. We discuss critical factors to be addressed for completing effective structural determinations and expose possible pitfalls of chemical methods. We survey programs developed for facilitating the interpretation of experimental data and discuss possible computational strategies for translating sparse spatial constraints into all-atom models. Examples are provided to illustrate how the concerted application of very diverse probing techniques can lead to the solution of actual biological systems.
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Registered trials
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