ArticleJournal of surgical oncology2010
Adjuvant external beam radiation for medullary thyroid carcinoma.
Article in Journal of surgical oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.Thyroid : official journal of the American Thyroid Association · 2015Guideline
- Machine-learning prediction of 3- and 5-year mortality in lymph-node-positive medullary thyroid carcinoma: a study based on the SEER database and external validation in a Chinese cohort.Frontiers in oncology · 2026Article
- Long-Term Follow-Up in Medullary Thyroid Carcinoma Patients.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025Review
- Well-defined survival outcome disparity across age cutoffs at 45 and 60 for medullary thyroid carcinoma: a long-term retrospective cohort study of 3601 patients.Frontiers in endocrinology · 2024Article
- Surgical aspects and controversies in the management of medullary thyroid cancer.Irish journal of medical science · 2022Review
- Metastatic medullary thyroid carcinoma: a new way forward.Endocrine-related cancer · 2022Review
- Evaluation of Survival and Postoperative Radiation Among Patients with Advanced Medullary Thyroid Carcinoma: An Analysis of the National Cancer Database.Annals of surgical oncology · 2022Article
- Prognosis of radiotherapy in medullary thyroid carcinoma patients without distant metastasis.Translational cancer research · 2021Article
- The role of postoperative adjuvant radiotherapy in the local control in medullary thyroid carcinoma.Endocrine connections · 2020Article
- Outcome of Treatment for Medullary Thyroid Carcinoma-a Single Centre Experience.Indian journal of surgical oncology · 2018Article
- Surgical management of medullary thyroid carcinoma.Updates in surgery · 2017Review
- Trends and Predictors of Chemotherapy Use among Thyroid Cancer Patients in the National Cancer Database (2004-2013).European thyroid journal · 2016Article
- Putative BRAF activating fusion in a medullary thyroid cancer.Cold Spring Harbor molecular case studies · 2016Article
- Recurrent spinal metastasis of a sporadic medullary carcinoma of the thyroid after radiation therapy: a case report and review of the literature.Clinical case reports · 2016Article
- Review
- Cabozantinib for progressive metastatic medullary thyroid cancer: a review.Therapeutics and clinical risk management · 2014Review
- Medullary thyroid cancer--current treatment strategy, novel therapies and perspectives for the future.Hormones & cancer · 2012Review
- Neutron radiation therapy for advanced thyroid cancers.Advances in radiation oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAdjuvant radiation is rarely used to treat medullary thyroid carcinoma (MTC). We hypothesized that external beam radiation therapy (EBRT) would improve overall survival (OS) in MTC patients.
methodsThe Surveillance, Epidemiology, and End Results (SEER) database identified patients who underwent total thyroidectomy and lymph nodes excision for MTC between 1988 and 2004. The Kaplan-Meier method was used for univariate comparisons of OS. Multivariate Cox proportional hazards models controlled for gender, age, lymph node status, tumor size, extent of disease, and EBRT.
resultsAfter 12 years, EBRT did not significantly improve OS (log rank, P < 0.14). In node-positive patients, univariate analysis demonstrated an OS benefit with EBRT (log rank, P < 0.05). In a multivariate model of node-positive patients, only increasing age (P < 0.001) and tumor size (P < 0.001) significantly influenced OS.
conclusionsThe OS benefit attributed to EBRT in node-positive patients by univariate analysis could not be duplicated when controlling for known prognostic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.