ArticleNanoscale2010
Multifunctional nanocomposites of superparamagnetic (Fe3O4) and NIR-responsive rare earth-doped up-conversion fluorescent (NaYF4 : Yb,Er) nanoparticles and their applications in biolabeling and fluorescent imaging of cancer cells.
Article in Nanoscale, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 164 citations in OpenAlex.
- Polymer-coated hexagonal upconverting nanoparticles: chemical stability and cytotoxicity.Frontiers in chemistry · 2023Article
- Prospects of Biosensors Based on Functionalized and Nanostructured Solitary Materials: Detection of Viral Infections and Other Risks.ACS omega · 2022Review
- Novel immunochromatographic strip assay based on up-conversion nanoparticles for sensitive detection of imidacloprid in agricultural and environmental samples.Environmental science and pollution research international · 2021Article
- Molecularly imprinted polymer-capped wrinkled silica-quantum dot hybrid particles for fluorescent determination of tetra bromo bisphenol A.Mikrochimica acta · 2021Article
- Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine.Nanomaterials (Basel, Switzerland) · 2020Review
- Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment.Journal of nanobiotechnology · 2020Review
- Magnetism and Afterglow United: Synthesis of Novel Double Core-Shell EuChemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Photothermal effects of NaYFInternational journal of nanomedicine · 2019Article
- Role of MnNanomaterials (Basel, Switzerland) · 2018Article
- Emission enhancement through NdApplied physics letters · 2017Article
- Synthesis, Characterization and Cytotoxicity of Novel Multifunctional Fe₃O₄@SiO₂@GdVO₄:DyMaterials (Basel, Switzerland) · 2016Article
- Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence.Chemical reviews · 2015Review
- Synthesis of NIR-Responsive NaYF₄:Yb,Er Upconversion Fluorescent Nanoparticles Using an Optimized Solvothermal Method and Their Applications in Enhanced Development of Latent Fingerprints on Various Smooth Substrates.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy.Beilstein journal of nanotechnology · 2015Review
- Photo-induced electric polarizability of Fe3O4 nanoparticles in weak optical fields.Nanoscale research letters · 2013Article
- Multifunctional upconversion-magnetic hybrid nanostructured materials: synthesis and bioapplications.Theranostics · 2013Review
- Magnetic and luminescent hybrid nanomaterial based on Fe(3)O(4) nanocrystals and GdPO(4):Eu(3+) nanoneedles.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2012Article
- Magnetic and optical properties of multifunctional core-shell radioluminescence nanoparticles.Journal of materials chemistry · 2012Article
- Novel microwave-assisted solvothermal synthesis of NaYF4:Yb,Er upconversion nanoparticles and their application in cancer cell imaging.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Upconversion nanoparticles: synthesis, surface modification and biological applications.Nanomedicine : nanotechnology, biology, and medicine · 2011Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
A new kind of magnetic/luminescent multifunctional nanoparticles was synthesized by covalently linking multiple carboxyl-functionalized superparamagnetic Fe(3)O(4) nanoparticles and individual amino-functionalized silica-coated fluorescent NaYF(4) : Yb,Er up-conversion nanoparticles (UCNPs). The resultant nanocomposites bear active carboxylic and amino groups on the surface that were proved to be chemically active and useful for further facile bioconjugation with biomolecules. The UCNPs in the nanocomposite particles can emit visible light in response to the irradiation by near infrared (NIR) light, enabling the application of the nanocomposites in bioimaging. X-Ray diffraction, infrared spectroscopy, transmission electron microscopy, luminescence spectroscopy, and magnetometry were applied to characterize the multifunctional nanocomposites. The nanocomposites exhibited good superparamagnetic and excellent green up-conversion photoluminescent properties that can be exploited in magnetic separation and guiding as well as bioimaging. Due to the presence of active functional groups on the nanocomposite surface, the Fe(3)O(4)/NaYF(4) : Yb,Er magnetic/luminescent nanocomposites were successfully conjugated with a protein called transferrin, which specifically recognizes the transferrin receptors overexpressed on HeLa cells, and can be employed for biolabeling and fluorescent imaging of HeLa cells. Because NIR light can penetrate biological samples with good depth without damaging them and can avoid autofluorescence from them, the presence of both NIR-responsive UCNPs and superparamagnetic nanoparticles in the nanocomposite particles will enable the practical application of the nanocomposites in bioimaging and separation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.