ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2010
Cerebral blood flow modeling in primate cortex.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Blood Flow Simulation and Uncertainty Quantification in Extensive Microvascular Networks: Application to Brain Cortical Networks.Microcirculation (New York, N.Y. : 1994) · 2025Article
- Approaches to vascular network, blood flow, and metabolite distribution modeling in brain tissue.Biophysical reviews · 2023Review
- The role of leptomeningeal collaterals in redistributing blood flow during stroke.PLoS computational biology · 2023Article
- The Venular Side of Cerebral Amyloid Angiopathy: Proof of Concept of a Neglected Issue.Biomedicines · 2023Review
- Article
- Adaptive constrained constructive optimisation for complex vascularisation processes.Scientific reports · 2021Article
- From whole-organ imaging to in-silico blood flow modeling: A new multi-scale network analysis for revisiting tissue functional anatomy.PLoS computational biology · 2020Article
- Article
- Red blood cells stabilize flow in brain microvascular networks.PLoS computational biology · 2019Article
- Article
- fMRI in Non-human Primate: A Review on Factors That Can Affect Interpretation and Dynamic Causal Modeling Application.Frontiers in neuroscience · 2019Review
- Patterns of Cortical Visual Field Defects From Embolic Stroke Explained by the Anastomotic Organization of Vascular Microlobules.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2018Review
- The morphology of the human cerebrovascular system.Human brain mapping · 2018Article
- Modeling the hematocrit distribution in microcirculatory networks: A quantitative evaluation of a phase separation model.Microcirculation (New York, N.Y. : 1994) · 2018Article
- Insights into cerebral haemodynamics and oxygenation utilising in vivo mural cell imaging and mathematical modelling.Scientific reports · 2018Article
- Article
- Model-based inference from microvascular measurements: Combining experimental measurements and model predictions using a Bayesian probabilistic approach.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Depth-dependent flow and pressure characteristics in cortical microvascular networks.PLoS computational biology · 2017Article
- Red blood cell phase separation in symmetric and asymmetric microchannel networks: effect of capillary dilation and inflow velocity.Scientific reports · 2016Article
- fMRI at High Spatial Resolution: Implications for BOLD-Models.Frontiers in computational neuroscience · 2016Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report new results on blood flow modeling over large volumes of cortical gray matter of primate brain. We propose a network method for computing the blood flow, which handles realistic boundary conditions, complex vessel shapes, and complex nonlinear blood rheology. From a detailed comparison of the available models for the blood flow rheology and the phase separation effect, we are able to derive important new results on the impact of network structure on blood pressure, hematocrit, and flow distributions. Our findings show that the network geometry (vessel shapes and diameters), the boundary conditions associated with the arterial inputs and venous outputs, and the effective viscosity of the blood are essential components in the flow distribution. In contrast, we show that the phase separation effect has a minor function in the global microvascular hemodynamic behavior. The behavior of the pressure, hematocrit, and blood flow distributions within the network are described through the depth of the primate cerebral cortex and are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.