ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2011
Neuroprotective signaling pathways are modulated by adenosine in the anoxia tolerant turtle.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Phosphoproteomic changes in response to anoxia are tissue-specific in the anoxia-tolerant crucian carp (Frontiers in physiology · 2024Article
- Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023Review
- Cerebral Oxygen Delivery and Consumption in Brain-Injured Patients.Journal of personalized medicine · 2022Review
- Differential Responses of Methionine Sulfoxide Reductases A and B to Anoxia and Oxidative Stress in the Freshwater TurtleMetabolites · 2021Article
- Induction of foxo3a protects turtle neurons against oxidative stress.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2020Article
- Preconditioning in neuroprotection: From hypoxia to ischemia.Progress in neurobiology · 2017Review
- Comparative Response of Brain to Chronic Hypoxia and Hyperoxia.International journal of molecular sciences · 2017Review
- Signaling pathways underlying the antidepressant-like effect of inosine in mice.Purinergic signalling · 2017Article
- Lessons from nature: signalling cascades associated with vertebrate brain anoxic survival.Experimental physiology · 2016Article
- A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway.Molecular brain · 2016Article
- Stimulation of Anterior Thalamic Nuclei Protects Against Seizures and Neuronal Apoptosis in Hippocampal CA3 Region of Kainic Acid-induced Epileptic Rats.Chinese medical journal · 2016Article
- Remote Ischemic Preconditioning and Protection of the Kidney--A Novel Therapeutic Option.Critical care medicine · 2016Article
- Upregulation of Hsp72 mediates anoxia/reoxygenation neuroprotection in the freshwater turtle via modulation of ROS.Brain research · 2014Article
- Mitochondria from anoxia-tolerant animals reveal common strategies to survive without oxygen.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Review
- No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates.The Journal of experimental biology · 2014Review
- Remote ischemic preconditioning and renoprotection: from myth to a novel therapeutic option?Journal of the American Society of Nephrology : JASN · 2014Review
- NeuroProtective effects of adenosine receptor agonist coadministration with ascorbic acid on CA1 hippocampus in a mouse model of ischemia reperfusion injury.Metabolic brain disease · 2013Article
- 3-Mercaptopropionic acid-induced repetitive seizures increase GluN2A expression in rat hippocampus: a potential neuroprotective role of cyclopentyladenosine.Cellular and molecular neurobiology · 2013Article
- Alleviating brain stress: what alternative animal models have revealed about therapeutic targets for hypoxia and anoxia.Future neurology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cumulative evidence shows a protective role for adenosine A1 receptors (A1R) in hypoxia/ischemia; A1R stimulation reduces neuronal damage, whereas blockade exacerbates damage. The signal transduction pathways may involve the mitogen-activated protein kinase (MAPK) pathways and serine/threonine kinase (AKT), with cell survival depending on the timing and degree of upregulation of these cascades as well as the balance between pro-survival and pro-death pathways. Here, we show in vitro that extracellular signal-regulated kinase (ERK1/2) and phosphatidylinositol 3-kinase (PI3-K/AKT) activation is dependent on A1R stimulation, with further downstream effects that promote neuronal survival. Phosphorylated ERK1/2 (p-ERK) and AKT (p-AKT) as well as Bcl-2 are upregulated in anoxic neuronally enriched primary cultures from turtle brain. This native upregulation is further increased by the selective A1R agonist 2-chloro-N-cyclopentyladenosine (CCPA), whereas the selective antagonist 8-cyclopentyl-1,3-dihydropylxanthine (DPCPX) decreases p-ERK and p-AKT expression. Conversely, A1R antagonism resulted in increases in phosphorylated JNK (p-JNK), p38 (p-p38), and Bax. As pathological and adaptive changes occur simultaneously during anoxia/ischemia in mammalian neurons, the turtle provides an alternative model to analyze protective mechanisms in the absence of evident pathologies.
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