ArticleJournal of hypertension2010
Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus.
Article in Journal of hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
120 citing papers in PubMed, 3 syntheses or guidelines pooled it, 248 citations in OpenAlex.
- Mapping arterial stiffness metabolic biomarkers: a bibliometric analysis.Frontiers in medicine · 2025Pooled it
- Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2015Guideline
- Update: ambulatory blood pressure monitoring in children and adolescents: a scientific statement from the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2014Guideline
- Exercise effects on arterial stiffness and heart health in children with excess weight: The SMART RCT.International journal of obesity (2005) · 2020Trial
- Heart Rate Variability and Cardiac Autonomic Dysfunction: Prevalence, Risk Factors, and Relationship to Arterial Stiffness in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.Diabetes care · 2019 · on this mapTrial
- Lipid Profiles, Inflammatory Markers, and Insulin Therapy in Youth with Type 2 Diabetes.The Journal of pediatrics · 2018 · on this mapTrial
- A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young healthy population.Nutrition journal · 2013Trial
- Insulin increases central aortic stiffness in response to hyperglycemia in healthy humans: A randomized four-arm study.Diabetes & vascular disease researchTrial
- Arterial Stiffness and Central Hemodynamics in South Asian, African American, and White Adolescents and Young Adults-The Charisma Study.American journal of hypertension · 2026Article
- Youth Blood Pressure and Target Organ Injury Markers: The SHIP AHOY Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Central arterial stiffness in young adults with perinatal HIV exposure and infection.AIDS (London, England) · 2025Article
- Dulaglutide and Dapagliflozin Combination Concurrently Improves the Endothelial Glycocalyx and Vascular and Myocardial Function in Patients with T2DM and Albuminuria vs. DPP-4i.Journal of clinical medicine · 2024Article
- Early-Life Risk Factors for Carotid Intima-Media Thickness and Carotid Stiffness in Adolescence.JAMA network open · 2024Article
- Should aortic stiffness parameters be used in MIS-C patient follow-up?The international journal of cardiovascular imaging · 2024Article
- The relationship betweenNorthern clinics of Istanbul · 2024Article
- Wall Properties of Elastic and Muscular Arteries in Children and Adolescents at Increased Cardiovascular Risk.Journal of clinical medicine · 2023Article
- The Level of Inflammatory Markers and Their Relationship with Fat Tissue Distribution in Children with Obesity and Type 2 Diabetes Mellitus.Turkish archives of pediatrics · 2023Article
- Effect of exogenous l-carnitine on aortic stiffness in dyslipidemic adolescents: Design of a quadruple-blind, randomized, controlled interventional trial.Contemporary clinical trials communications · 2023Article
- Article
- Can Surrogate Markers Help Define Cardiovascular Disease in Youth?Current atherosclerosis reports · 2023Review
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveAdults with obesity or obesity-related type 2 diabetes (T2DM) are at higher risk for cardiovascular disease possibly due to increased arterial stiffness. We sought to determine if arterial stiffness is increased in youth with obesity or T2DM as compared with lean controls.
methodsYouth age 10-24 years (N = 670, 62% non-Caucasian, 35% male) were examined. They were stratified by the 85th% of BMI as lean (L=241), obese (O=234) or obese with T2DM (T2DM=195). Questionnaire, anthropometric, BP, laboratory (fasting glucose, insulin, HbA1c, lipids, CRP), physical activity, and DXA were collected. Brachial artery distensibility (BrachD), pulse wave velocity (PWV) and augmentation index (AIx) were measured. Group differences were evaluated by ANOVA. General linear multivariate models were constructed to elucidate independent determinates of arterial stiffness.
resultsCV risk profile deteriorated from L to O to T2DM group. There was a progressive increase in AIx and PWV-trunk with progressive decline in BrachD from L to O to T2DM individuals (all P < 0.05). Group (status as L, O or T2DM) was an independent predictor of arterial stiffness even after adjusting for CV risk factors.
conclusionArterial stiffness is increased in young individuals with obesity and obesity-related T2DM even after correction for risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.