ArticleMolecular and cellular biology2010
A novel mechanism for SUMO system control: regulated Ulp1 nucleolar sequestration.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Dynamic sumoylation is essential in yeast for suppressing stress-induced gene expression in non-stress conditions.Nucleic acids research · 2026Article
- Article
- 1,10-phenanthroline inhibits sumoylation and reveals that yeast SUMO modifications are highly transient.EMBO reports · 2024Article
- Sumoylation is Largely Dispensable for Normal Growth but Facilitates Heat Tolerance in Yeast.Molecular and cellular biology · 2023Article
- A nuclear pore sub-complex restricts the propagation of Ty retrotransposons by limiting their transcription.PLoS genetics · 2021Article
- Nucleolar Sequestration: Remodeling Nucleoli Into Amyloid Bodies.Frontiers in genetics · 2019Article
- Elevated dosage of Ulp1 disrupts telomeric silencing in Saccharomyces cerevisiae.Molecular biology reports · 2018Article
- A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits.Nature communications · 2018Article
- SUMO targeting of a stress-tolerant Ulp1 SUMO protease.PloS one · 2018Article
- SUMO and the robustness of cancer.Nature reviews. Cancer · 2017Review
- Identification of Components of the SUMOylation Machinery in Candida glabrata: ROLE OF THE DESUMOYLATION PEPTIDASE CgUlp2 IN VIRULENCE.The Journal of biological chemistry · 2016Article
- SUMO Pathway Modulation of Regulatory Protein Binding at the Ribosomal DNA Locus in Saccharomyces cerevisiae.Genetics · 2016Article
- Sumoylation of Sir2 differentially regulates transcriptional silencing in yeast.Nucleic acids research · 2015Article
- Sumoylation and transcription regulation at nuclear pores.Chromosoma · 2015Review
- SUMOylation is developmentally regulated and required for cell pairing during conjugation in Tetrahymena thermophila.Eukaryotic cell · 2015Article
- Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs.Nucleic acids research · 2014Article
- Starting and stopping SUMOylation. What regulates the regulator?Chromosoma · 2013Review
- A global S. cerevisiae small ubiquitin-related modifier (SUMO) system interactome.Molecular systems biology · 2013Article
- Loss of SUMOylation on ATF3 inhibits proliferation of prostate cancer cells by modulating CCND1/2 activity.International journal of molecular sciences · 2013Article
- STUbLs in chromatin and genome stability.Biopolymers · 2013Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The small ubiquitin-related modifiers (SUMOs) are evolutionarily conserved polypeptides that are covalently conjugated to protein targets to modulate their subcellular localization, half-life, or activity. Steady-state SUMO conjugation levels increase in response to many different types of environmental stresses, but how the SUMO system is regulated in response to these insults is not well understood. Here, we characterize a novel mode of SUMO system control: in response to elevated alcohol levels, the Saccharomyces cerevisiae SUMO protease Ulp1 is disengaged from its usual location at the nuclear pore complex (NPC) and sequestered in the nucleolus. We further show that the Ulp1 region previously demonstrated to interact with the karyopherins Kap95 and Kap60 (amino acids 150 to 340) is necessary and sufficient for nucleolar targeting and that enforced sequestration of Ulp1 in the nucleolus significantly increases steady-state SUMO conjugate levels, even in the absence of alcohol. We have thus characterized a novel mechanism of SUMO system control in which the balance between SUMO-conjugating and -deconjugating activities at the NPC is altered in response to stress via relocalization of a SUMO-deconjugating enzyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.