ArticleThe Journal of pharmacology and experimental therapeutics2010
17beta-estradiol rapidly enhances bradykinin signaling in primary sensory neurons in vitro and in vivo.
Article in The Journal of pharmacology and experimental therapeutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Estrogen Status and Trigeminal Ganglion Responses to Jaw Movement.Journal of dental research · 2022Article
- Comparing Gene Expression in the Parabrachial and Amygdala of Diestrus and Proestrus Female Rats after Orofacial Varicella Zoster Injection.International journal of molecular sciences · 2020Article
- Sex Differences in Estradiol Secretion by Trigeminal Brainstem Neurons.Frontiers in integrative neuroscience · 2019Article
- Review
- Functional selectivity of kappa opioid receptor agonists in peripheral sensory neurons.The Journal of pharmacology and experimental therapeutics · 2015Article
- Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms.Pain · 2015Article
- Estradiol attenuates spinal cord injury-related central pain by decreasing glutamate levels in thalamic VPL nucleus in male rats.Metabolic brain disease · 2014Article
- Sex and the migraine brain.Neurobiology of disease · 2014Review
- Activation of estrogen receptor α enhances bradykinin signaling in peripheral sensory neurons of female rats.The Journal of pharmacology and experimental therapeutics · 2014Article
- Sex differences and hormonal modulation of deep tissue pain.Frontiers in neuroendocrinology · 2013Review
- Transdermal hormonal therapy in perimenstrual migraine: why, when and how?Current pain and headache reports · 2012Review
- Rapid estrogenic effects on TMJ-responsive brainstem neurons.Journal of dental research · 2012Article
- A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Estrogen exacerbates the nociceptive effects of peripheral serotonin on rat trigeminal sensory neurons.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Many studies have demonstrated that premenopausal women are at increased risk for various pain disorders. Pain-sensing neurons, termed "nociceptors," in the trigeminal ganglia (TG) and dorsal root ganglia (DRG) express receptors for inflammatory mediators and noxious physical stimuli and transmit signals for central processing of pain sensation. Estrogen receptors (ERs) are also expressed on nociceptors in the TG and DRG, and there is ample literature to suggest that activation of ERs can influence pain mechanisms. However, the mechanism for ER modulation of nociceptor activity is incompletely understood. The aim of this study was to characterize the effect of 17β-estradiol (17β-E(2)) on signaling of the inflammatory mediator bradykinin (BK) in primary cultures of rat sensory neurons and a behavioral model of thermal allodynia in rats. Here, we show that exposure to 17β-E(2) rapidly (within 15 min) enhanced responses to BK in vitro and in vivo. The 17β-E(2)-mediated enhancement of BK signaling was not blocked by the transcription inhibitor anisomycin and was mediated by a membrane-associated ER. The effect of 17β-E(2) to enhance BK responses required activation of β1-containing, RGD-binding integrins. These data show that 17β-E(2) rapidly enhances inflammatory mediator responses both in vitro and in vivo and suggest that 17β-E(2) acting at primary sensory pain neurons may participate in regulating the sensitivity of women to painful stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.