ArticleScience (New York, N.Y.)2010
Hedgehog signaling regulates segment formation in the annelid Platynereis.
Article in Science (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 104 citations in OpenAlex.
- Hedgehog Signaling during Gut Formation in the Freshwater Leech, Helobdella austinensis.Cells, tissues, organs · 2025Article
- Transcriptomic landscape of posterior regeneration in the annelid Platynereis dumerilii.BMC genomics · 2023Article
- Spatial transcriptomics reveals a conserved segment polarity program that governs muscle patterning inbioRxiv : the preprint server for biology · 2023Article
- Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core.International journal of molecular sciences · 2022Article
- Distinct patterns of gene expression during regeneration and asexual reproduction in the annelid Pristina leidyi.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Article
- Lack of evidence for conserved parasegmental grooves in arthropods.Development genes and evolution · 2022Article
- Article
- How Weird is The Worm? Evolution of the Developmental Gene Toolkit inJournal of developmental biology · 2019Review
- Embryonic expression of priapulid Wnt genes.Development genes and evolution · 2019Article
- Transcriptome Analysis of Larval Segment Formation and Secondary Loss in the Echiuran WormInternational journal of molecular sciences · 2019Article
- Article
- A Revised Spiralian Homeobox Gene Classification Incorporating New Polychaete Transcriptomes Reveals a Diverse TALE Class and a Divergent Hox Gene.Genome biology and evolution · 2018Article
- PdumBase: a transcriptome database and research tool for Platynereis dumerilii and early development of other metazoans.BMC genomics · 2018Article
- The Notch pathway in the annelid Platynereis: insights into chaetogenesis and neurogenesis processes.Open biology · 2017Article
- Ancient role ofHereditas · 2017Article
- Article
- Expression of segment polarity genes in brachiopods supports a non-segmental ancestral role of engrailed for bilaterians.Scientific reports · 2016Article
- High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin.Nature biotechnology · 2015Article
- Scenarios for the making of vertebrates.Nature · 2015Review
- A metameric origin for the annelid pygidium?BMC evolutionary biology · 2015Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Annelids and arthropods share a similar segmented organization of the body whose evolutionary origin remains unclear. The Hedgehog signaling pathway, prominent in arthropod embryonic segment patterning, has not been shown to have a similar function outside arthropods. We show that the ligand Hedgehog, the receptor Patched, and the transcription factor Gli are all expressed in striped patterns before the morphological appearance of segments in the annelid Platynereis dumerilii. Treatments with small molecules antagonistic to Hedgehog signaling disrupt segment formation. Platynereis Hedgehog is not necessary to establish early segment patterns but is required to maintain them. The molecular similarity of segment patterning functions of the Hedgehog pathway in an annelid and in arthropods supports a common origin of segmentation in protostomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.