ArticleCancer prevention research (Philadelphia, Pa.)2010
Factors affecting the decision of breast cancer patients to undergo contralateral prophylactic mastectomy.
Article in Cancer prevention research (Philadelphia, Pa.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Deimplementation of the Choosing Wisely Recommendations for Low-Value Breast Cancer Surgery: A Systematic Review.JAMA surgery · 2020Pooled it
- Risk-reducing mastectomy for the prevention of primary breast cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Contralateral prophylactic mastectomy after unilateral breast cancer: a systematic review and meta-analysis.Annals of surgery · 2014Pooled it
- Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients: findings from a randomised controlled trial.British journal of cancer · 2014Trial
- Emotional Reactivity and Regulation Relate to Surgical Treatment Decision Making Among Newly Diagnosed Women With Breast Cancer.Cancer medicine · 2024Article
- Contralateral prophylactic mastectomy in a rural population: A single-institution experience.Surgery open science · 2024Article
- BRCA1/2 mutation carriers & risk reducing mastectomy: Who undergoes surgery and potential benefits.American journal of surgery · 2024Article
- Pain associated with breast cancer: etiologies and therapies.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Contralateral Prophylactic Mastectomy among Women with Pathogenic Variants inThe breast journal · 2022Article
- Preoperative diagnosis of BRCA1/2 mutation impacts decision-making for risk-reducing mastectomy in breast cancer patients.Scientific reports · 2021Article
- Genetic testing and surgical treatment after breast cancer diagnosis: Results from a national online cohort.Journal of surgical oncology · 2021Article
- Influencers of the Decision to Undergo Contralateral Prophylactic Mastectomy among Women with Unilateral Breast Cancer.Cancers · 2021Article
- Contralateral prophylactic mastectomy and implications for breast reconstruction.Gland surgery · 2021Review
- Second primary breast cancer after unilateral mastectomy alone or with contralateral prophylactic mastectomy.Cancer medicine · 2020Article
- Laterality and Patient-Reported Outcomes following Autologous Breast Reconstruction with Free Abdominal Tissue: An 8-Year Examination of BREAST-Q Data.Plastic and reconstructive surgery · 2020Article
- Modern surgical treatment of breast cancer.Annals of medicine and surgery (2012) · 2020Review
- Predictors of contralateral prophylactic mastectomy in genetically high risk newly diagnosed breast cancer patients.Breast cancer research and treatment · 2020Article
- Rate of BRCA mutation in patients tested under NCCN genetic testing criteria.American journal of surgery · 2020Article
- Trends in contralateral prophylactic mastectomy rate according to clinicopathologic and socioeconomic status.Annals of surgical treatment and research · 2019Article
- Discussion: Risk-to-Benefit Relationship of Contralateral Prophylactic Mastectomy: The Argument for Bilateral Mastectomies with Immediate Reconstruction.Plastic and reconstructive surgery · 2019Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Increasing numbers of women with breast cancer are electing for contralateral prophylactic mastectomy (CPM) to reduce the risk of developing contralateral breast cancer. The objective of this study was to identify factors that may affect a patient's decision to undergo CPM. We identified 2,504 women with stage 0 to III unilateral primary breast cancer who underwent breast surgery at our institution from January 2000 to August 2006 from a prospectively maintained database. We did logistic regression analyses to determine which factors were associated with undergoing CPM. Of 2,504 breast cancer patients, 1,223 (48.8%) underwent total mastectomy. Of the 1,223 patients who underwent mastectomy, 284 (23.2%) underwent immediate or delayed CPM. There were 33 patients (1.3%) who had genetic testing before the surgery, with the use of testing increasing in the latter years of the study (0.1% in 2000-2002 versus 2.0% in 2003-2006; P < 0.0001). Multivariable analysis revealed several factors that were associated with a patient undergoing CPM: age younger than 50 years, white ethnicity, family history of breast cancer, BRCA1/2 mutation testing, invasive lobular histology, clinical stage, and use of reconstruction. We identified specific patient and tumor characteristics associated with the use of CPM. Although genetic testing is increasing, most women undergoing CPM did not have a known genetic predisposition to breast cancer. Evidence-driven models are needed to better inform women of their absolute risk of contralateral breast cancer as well as their competing risk of recurrence from the primary breast cancer to empower them in their active decision making.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.