ArticleBrain : a journal of neurology2010
Approaching objects cause confusion in patients with Alzheimer's disease regarding their direction of self-movement.
Article in Brain : a journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Vestibular facilitation of optic flow parsing.PloS one · 2012Trial
- Independent deficits of visual word and motion processing in aging and early Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2012Trial
- Multisensory visual-vestibular training improves visual heading estimation in younger and older adults.Frontiers in aging neuroscience · 2022Article
- Stereoscopic Depth Perception and Visuospatial Dysfunction in Alzheimer's Disease.Healthcare (Basel, Switzerland) · 2021Article
- Causal inference accounts for heading perception in the presence of object motion.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Dissociation of Self-Motion and Object Motion by Linear Population Decoding That Approximates Marginalization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Multisensory Integration of Visual and Vestibular Signals Improves Heading Discrimination in the Presence of a Moving Object.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- At the interface of sensory and motor dysfunctions and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- Perceiving Collision Impacts in Alzheimer's Disease: The Effect of Retinal Eccentricity on Optic Flow Deficits.Frontiers in aging neuroscience · 2015Article
- Article
- Visual motion event related potentials distinguish aging and Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2013Article
- Driving strategy alters neuronal responses to self-movement: cortical mechanisms of distracted driving.Cerebral cortex (New York, N.Y. : 1991) · 2012Article
- Distinct visual motion processing impairments in aging and Alzheimer's disease.Vision research · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Navigation requires real-time heading estimation based-on self-movement cues from optic flow and object motion. We presented a simulated heading discrimination task to young, middle-aged and older adult, normal, control subjects and to patients with mild cognitive impairment or Alzheimer's disease. Age-related decline and neurodegenerative disease effects were evident on a battery of neuropsychological and visual motion psychophysical measures. All subject groups made more accurate heading judgements when using optic flow patterns than when using simulated movement past earth-fixed objects. When both optic flow and congruent object were presented together, heading judgements showed intermediate accuracy. In separate trials, we combined optic flow with non-congruent object motion, simulating an independently moving object. In the case of non-congruent objects, almost all of our subjects shifted their perceived self-movement to heading in the direction of the moving object. However, patients with Alzheimer's disease uniquely indicated that perceived self-movement was straight-ahead, in the direction of visual fixation. The tendency to be confused by objects that appear to move independently in the simulated visual scene corresponded to the difficulty patients with Alzheimer's disease encountered in real-world navigation through the hospital lobby (R(2) = 0.87). This was not the case in older normal controls (R(2) = 0.09). We conclude that perceptual factors limit safe, autonomous navigation in early Alzheimer's disease. In particular, the presence of independently moving objects in naturalistic environments limits the capacity of patients with Alzheimer's disease to judge their heading of self-movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.