ArticleThe New England journal of medicine2010
Genetic ancestry in lung-function predictions.
Article in The New England journal of medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03248869 (Asthma Mobile Health Application 2.0), which is not on this map. Cited by 146 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Asthma Mobile Health Application 2.0
Who cites it
146 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genetic ancestry is associated with asthma, and this could be modified by environmental factors. A systematic review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Pooled it
- Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.Human molecular genetics · 2014Pooled it
- A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.The Journal of allergy and clinical immunology · 2013Pooled it
- Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials.The Journal of allergy and clinical immunology · 2019Trial
- Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.The New England journal of medicine · 2019Trial
- Race is associated with differences in airway inflammation in patients with asthma.The Journal of allergy and clinical immunology · 2017Trial
- African ancestry, early life exposures, and respiratory morbidity in early childhood.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Trial
- Impact of race on asthma treatment failures in the asthma clinical research network.American journal of respiratory and critical care medicine · 2011Trial
- Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program.The Journal of allergy and clinical immunology · 2010Trial
- Current Practices and Preferences Regarding Race and Spirometry Interpretation: A National Survey.CHEST pulmonary · 2026Article
- Pediatric Pulmonology Year in Review 2024: Physiology.Pediatric pulmonology · 2025Review
- PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Ethnic disparities in hypertensive disorders of pregnancy.Reproduction (Cambridge, England) · 2025Review
- Risk Factors of FEV₁/FVC Decline in COPD Patients.Journal of Korean medical science · 2025Observational
- Is it time to end race and ethnicity adjustment for pediatric pulmonary function tests?Pediatric pulmonology · 2024Review
- Perspectives on Using Race in Pulmonary Function Testing: A National Survey Fellows and Program Directors.Respiratory care · 2024Article
- Impact of race-neutral global reference equations on spirometry interpretation in healthy children in The Gambia.IJTLD open · 2024Article
- Implications of Race Adjustment in Lung-Function Equations.The New England journal of medicine · 2024Article
- FEVThe European respiratory journal · 2024Article
- Association of Preoperative Lung Function with Complications after Lobectomy Using Race-Neutral and Race-Specific Normative Equations.Annals of the American Thoracic Society · 2024Article
- Impact of Spirometry Race-Correction on Preadolescent Black and White Children.The journal of allergy and clinical immunology. In practice · 2023Article
86 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors.
Funding
Abstract
backgroundSelf-identified race or ethnic group is used to determine normal reference standards in the prediction of pulmonary function. We conducted a study to determine whether the genetically determined percentage of African ancestry is associated with lung function and whether its use could improve predictions of lung function among persons who identified themselves as African American.
methodsWe assessed the ancestry of 777 participants self-identified as African American in the Coronary Artery Risk Development in Young Adults (CARDIA) study and evaluated the relation between pulmonary function and ancestry by means of linear regression. We performed similar analyses of data for two independent cohorts of subjects identifying themselves as African American: 813 participants in the Health, Aging, and Body Composition (HABC) study and 579 participants in the Cardiovascular Health Study (CHS). We compared the fit of two types of models to lung-function measurements: models based on the covariates used in standard prediction equations and models incorporating ancestry. We also evaluated the effect of the ancestry-based models on the classification of disease severity in two asthma-study populations.
resultsAfrican ancestry was inversely related to forced expiratory volume in 1 second (FEV(1)) and forced vital capacity in the CARDIA cohort. These relations were also seen in the HABC and CHS cohorts. In predicting lung function, the ancestry-based model fit the data better than standard models. Ancestry-based models resulted in the reclassification of asthma severity (based on the percentage of the predicted FEV(1)) in 4 to 5% of participants.
conclusionsCurrent predictive equations, which rely on self-identified race alone, may misestimate lung function among subjects who identify themselves as African American. Incorporating ancestry into normative equations may improve lung-function estimates and more accurately categorize disease severity. (Funded by the National Institutes of Health and others.)
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