ArticleTrends in biotechnology2010
From complete genome sequence to 'complete' understanding?
Article in Trends in biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
89 citing papers in PubMed.
- Spatiotemporal single-cell architecture of gene expression in the Caenorhabditis elegans germ cells.Cell discovery · 2025Article
- Whole genome sequence analysis of shallot virus X from India reveals it to be a natural recombinant with positive selection pressure.BMC genomic data · 2024Article
- A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology.Nature communications · 2023Article
- Beyond the limits of the unassigned protist microbiome: inferring large-scale spatio-temporal patterns of Syndiniales marine parasites.ISME communications · 2023Article
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- Conservation and Diversification of tRNA tInternational journal of molecular sciences · 2022Review
- Marine Bioprospecting, Biocatalysis and Process Development.Microorganisms · 2022Review
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- Expanding biochemical knowledge and illuminating metabolic dark matter with ATLASx.Nature communications · 2022Article
- Using Genome Scale Mutant Libraries to Identify Essential Genes.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Whole-genome sequencing of a year-round fruiting jackfruit (Frontiers in plant science · 2022Article
- Fundamentals to function: Quantitative and scalable approaches for measuring protein stability.Cell systems · 2021Review
- Modeling factors critical for implementation of precision medicine at health systems-level: an IRT approach.American journal of translational research · 2021Article
- Construction of a complete set of Neisseria meningitidis mutants and its use for the phenotypic profiling of this human pathogen.Nature communications · 2020Article
- Article
- Systems Biochemistry Approaches to Defining Mitochondrial Protein Function.Cell metabolism · 2020Review
- Zmo0994, a novel LEA-like protein fromBiotechnology for biofuels · 2020Article
- The Link Between the Ecology of the Prokaryotic Rare Biosphere and Its Biotechnological Potential.Frontiers in microbiology · 2020Review
- Microbial genome analysis: the COG approach.Briefings in bioinformatics · 2019Review
- Analysis of UncharacterizedJournal of cardiovascular development and disease · 2019Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The rapidly accumulating genome sequence data allow researchers to address fundamental biological questions that were not even asked just a few years ago. A major problem in genomics is the widening gap between the rapid progress in genome sequencing and the comparatively slow progress in the functional characterization of sequenced genomes. Here we discuss two key questions of genome biology: whether we need more genomes, and how deep is our understanding of biology based on genomic analysis. We argue that overly specific annotations of gene functions are often less useful than the more generic, but also more robust, functional assignments based on protein family classification. We also discuss problems in understanding the functions of the remaining 'conserved hypothetical' genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.