ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2010
Heritability of measures of kidney disease among Zuni Indians: the Zuni Kidney Project.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Health Disparity in Chronic Kidney Disease in Zuni Indians
Home-Based Chronic Kidney Disease (CKD) Care in Native American's of New Mexico- A Disruptive Innovation
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Pooled it
- Pooled it
- The association of genetic variants of type 2 diabetes with kidney function.Kidney international · 2012Pooled it
- Diabetes status modifies the efficacy of home-based kidney care for Zuni Indians in a randomized controlled trial.Journal of diabetes and its complications · 2021Trial
- Multifaceted role of inosine in complex diseases and human health.Nutrition reviews · 2025Review
- The Effect of PPARγ rs1801282 Variant on Mortality Risk Among Asians With Chronic Kidney Disease: A Cohort Study and Meta-Analysis.Frontiers in genetics · 2022Article
- Article
- Association betweenJournal of clinical medicine · 2021Article
- Contribution of Rare Variants of theGenetics · 2020Article
- Refining genome-wide associated loci for serum uric acid in individuals with African ancestry.Human molecular genetics · 2020Article
- Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.Nature genetics · 2019Article
- Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.Nature communications · 2019Article
- The systemic nature of CKD.Nature reviews. Nephrology · 2017Review
- Genetic and environmental influences on the associations between change in kidney function and changes in cardiometabolic factors in Koreans.Clinical and experimental nephrology · 2017Article
- Using the Centers for Disease Control and Prevention's Stay Independent Checklist to Engage a Community of American Indians and Raise Awareness About Risk of Falls, 2016.Preventing chronic disease · 2017Article
- Blueberry Consumption Affects Serum Uric Acid Concentrations in Older Adults in a Sex-Specific Manner.Antioxidants (Basel, Switzerland) · 2016Article
- Exercise Intervention Improves the Metabolic Profile and Body Composition of Southwestern American Indian Adolescents.Journal of diabetes and obesity · 2016Article
- Longitudinal relationships of metabolic syndrome and obesity with kidney function: Healthy Twin Study.Clinical and experimental nephrology · 2015Article
- Genetics of diabetic nephropathy: a long road of discovery.Current diabetes reports · 2015Review
- Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study.The American journal of clinical nutrition · 2015Article
Corrections and comments
- Commented on by
Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe long-term goal of the GKDZI (Genetics of Kidney Disease in Zuni Indians) Study is to identify genes, environmental factors, and genetic-environmental interactions that modulate susceptibility to renal disease and intermediate phenotypes. STUDY
designA community-based participatory research approach was used to recruit family members of individuals with kidney disease. SETTING &
participantsThe study was conducted in the Zuni Indians, a small endogamous tribe located in rural New Mexico. We recruited members of extended families, ascertained through a proband with kidney disease and at least 1 sibling with kidney disease. 821 participants were recruited, comprising 7,702 relative pairs. PREDICTOR OUTCOMES & MEASUREMENTS: Urine albumin-creatinine ratio (UACR) and hematuria were determined in 3 urine samples and expressed as a true ratio. Glomerular filtration rate (GFR) was estimated using the Modification of Diet in Renal Disease (MDRD) Study equation modified for American Indians. Probands were considered to have kidney disease if UACR was >or=0.2 in 2 or more of 3 spot urine samples or estimated GFR was decreased according to the CRIC (Chronic Renal Insufficiency Cohort) Study criteria.
resultsKidney disease was identified in 192 participants (23.4%). There were significant heritabilities for estimated GFR, UACR, serum creatinine, serum urea nitrogen, and uric acid and a variety of phenotypes related to obesity, diabetes, and cardiovascular disease. There were significant genetic correlations of some kidney-related phenotypes with these other phenotypes. LIMITATIONS: Limitations include absence of renal biopsy, possible misclassification bias, lack of direct GFR measurements, and failure to include all possible environmental interactions.
conclusionsMany phenotypes related to kidney disease showed significant heritabilities in Zuni Indians, and there were significant genetic correlations with phenotypes related to obesity, diabetes, and cardiovascular disease. The study design serves as a paradigm for the conduct of research in relatively isolated, endogamous, underserved populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.