Evidence map›Paper›PMID 20646772›Full record

ReviewJournal of hepatology2010

Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications.

J U Marquardt, V M Factor, S S Thorgeirsson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of hepatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J U MarquardtLaboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, MD, USA.
V M Factor
S S Thorgeirsson

Funding

Cancer stem cells and human liver cancerZIABC011031 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI THORGEIRSSON, SNORRI · 2009 to 2014
$3.7M
Intramural NIH HHS ZIA BC011031
6 · The paper itself

Abstract

The two dominant models of carcinogenesis postulate stochastic (clonal evolution) or hierarchic organization of tumor (cancer stem cell model). According to the latter, at the germinal center of tumor evolution is a cancer stem cell (CSC) which, similar to normal adult stem cells, possesses the capacity of self-renewal and a differentiation potential. Over the past few years, compelling evidence has emerged in support of the hierarchic cancer model for many solid tumors including hepatocellular cancers. The CSCs are posited to be responsible not only for tumor initiation but also for the generation of distant metastasis and relapse after therapy. These characteristics are particularly relevant for a multi-resistant tumor entity like human hepatocellular carcinoma and may herald a paradigm shift in the management of this deadly disease. Identification and detailed characterization of liver CSCs is therefore imperative for improving prevention approaches, enhancing early detection, and extending the limited treatment options. Despite the current progress in understanding the contribution of CSCs to the generation of heterogeneity of tumors, the molecular complexity and exact regulation of CSCs is poorly understood. This review focuses on the genetic and epigenetic mechanisms that regulate and define the unique CSC properties with an emphasis on key regulatory pathways of liver CSCs and their clinical significance.

Indexed as

Epigenesis, GeneticAC133 AntigenAldehyde DehydrogenaseAntigens, CDAntigens, Neoplasmbeta CateninCarcinoma, HepatocellularCell Adhesion MoleculesCell DivisionCell SeparationEpithelial Cell Adhesion MoleculeGenes, mycGlycoproteinsHedgehog ProteinsHumansLiver NeoplasmsAC133 AntigenAldehyde DehydrogenaseAntigens, CDAntigens, Neoplasmbeta CateninBMI1 protein, humanCell Adhesion MoleculesCTNNB1 protein, humanEPCAM protein, humanEpithelial Cell Adhesion MoleculeGlycoproteinsHedgehog ProteinsMicroRNAsNuclear ProteinsPeptidesPolycomb Repressive Complex 1Proto-Oncogene ProteinsReceptors, NotchRepressor ProteinsRNA, NeoplasmSHH protein, humanThy-1 AntigensTransforming Growth Factor betaWnt Proteins

Identifiers

PMID20646772
PMCPMC3492877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.