ArticleMicrobial cell factories2010
An antibiotic, heavy metal resistant and halotolerant Bacillus cereus SIU1 and its thermoalkaline protease.
Article in Microbial cell factories, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
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- Performance of microbial community dominated byHeliyon · 2021Article
- Potential Plant Growth-Promoting Bacteria with Heavy Metal Resistance.Current microbiology · 2020Article
- Draft Genome Sequence of Heavy Metal-Resistant Bacillus cereus NWUAB01.Microbiology resource announcements · 2019Article
- Enhanced Production and Characterization of a Highly Stable Extracellular Protease from an Extreme Halophilic IsolateIranian journal of pharmaceutical research : IJPR · 2018Article
- Biosorption of lead phosphates by lead-tolerant bacteria as a mechanism for lead immobilization.World journal of microbiology & biotechnology · 2017Article
- Microbial alkaline proteases: Optimization of production parameters and their properties.Journal, genetic engineering & biotechnology · 2017Review
- The gut microbiome and degradation enzyme activity of wild freshwater fishes influenced by their trophic levels.Scientific reports · 2016Article
- Microbial growth under supercritical CO2.Applied and environmental microbiology · 2015Article
- Combined toxic effects of heavy metals and antibiotics on a Pseudomonas fluorescens strain ZY2 isolated from swine wastewater.International journal of molecular sciences · 2015Article
- Biosequestration of lead using Bacillus strains isolated from seleniferous soils and sediments of Punjab.Environmental science and pollution research international · 2014Article
- The effect of microdosimetric 12C6+ heavy ion irradiation and Mg2+ on canthaxanthin production in a novel strain of Dietzia natronolimnaea.BMC microbiology · 2013Article
- Improvement of Desferrioxamine B Production of Streptomyces pilosus ATCC 19797 With Use of Protease Inhibitor and Minerals Related to Its Activity.Indian journal of clinical biochemistry : IJCB · 2012Article
- Comparative one-factor-at-a-time, response surface (statistical) and bench-scale bioreactor level optimization of thermoalkaline protease production from a psychrotrophic Pseudomonas putida SKG-1 isolate.Microbial cell factories · 2011Article
- A study on trypsin, Aspergillus flavus and Bacillus sp. protease inhibitory activity in Cassia tora (L.) syn Senna tora (L.) Roxb. seed extract.BMC complementary and alternative medicine · 2011Article
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5 authors.
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Abstract
backgroundMany workers have reported halotolerant bacteria from saline conditions capable of protease production. However, antibiotic resistance and heavy metal tolerance pattern of such organisms is not documented very well. Similarly, only a few researchers have reported the pattern of pH change of fermentation medium during the course of protease production. In this study, we have isolated a halotolerant Bacillus cereus SIU1 strain from a non-saline environment and studied its antibiotic and heavy metal resistance pattern. The isolate produces a thermoalkaline protease and changes the medium pH during the course of fermentation. Thermostability of protease was also studied for 30 min.
resultsSeventy bacterial strains isolated from the soils of Eastern Uttar Pradesh, India were screened for protease production. All of them exhibited protease activity. However, 40% bacterial isolates were found good protease producers as observed by caseinolytic zones on milk agar plates. Among them, culture S-4 was adjudged as the best protease producer, and was identified as Bacillus cereus by morphological, biochemical and 16 S rDNA sequence analyses. The isolate was resistant to heavy metals (As2+, Pb2+, Cs1+) and antibiotics (penicillin, lincomycin, cloxacillin, pefloxacin). Its growth behavior and protease production was studied at 45 degrees C and pH 9.0. The protease units of 88 ml-1 were noted in unoptimized modified glucose yeast extract (GYE) medium during early stationary phase at 20 h incubation period. The enzyme was stable in the temperature range of 35 degrees-55 degrees C.
conclusionsAn antibiotic and heavy metal resistant, halotolerant Bacillus cereus isolate is capable of producing thermoalkaline protease, which is active and stable at pH 9.0 and 35 degrees-55 degrees C. This isolate may be useful in several industrial applications owing to its halotolerance and antibiotic and heavy metal resistance characteristics.
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