ArticleInternational urogynecology journal2010
An open multicenter study of polyacrylamide hydrogel (Bulkamid®) for female stress and mixed urinary incontinence.
Article in International urogynecology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02538991 (TVT Versus Bulkamid®-Injections in Treatment of Stress Urinary Incontinence - Patient Satisfaction and Complications of the Treatment), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TVT Versus Bulkamid®-Injections in Treatment of Stress Urinary Incontinence - Patient Satisfaction and Complications of the Treatment
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Intraurethral bulking agents for the management of female stress urinary incontinence: a systematic review.International urogynecology journal · 2017Pooled it
- Polyacrylamide hydrogel (Bulkamid®) for stress urinary incontinence in women: a systematic review of the literature.International urogynecology journal · 2016Pooled it
- The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review.Clinics (Sao Paulo, Brazil) · 2016Pooled it
- Quality of life and sexual function after tension-free vaginal tape and polyacrylamide hydrogel injection for primary stress urinary incontinence: 3-year follow-up from a randomized clinical trial.International urogynecology journal · 2023Trial
- Quality of life and sexual function after TVT surgery versus Bulkamid injection for primary stress urinary incontinence: 1 year results from a randomized clinical trial.International urogynecology journal · 2021Trial
- Hydrogel-Based Therapies for Female Stress Urinary Incontinence: From Bulking Agents to Regenerative Platforms-A Narrative Review.Current urology reports · 2026Review
- Submucosal urethral bulking with 2.5% polyacrylamide hydrogel (Mictamid) for urinary incontinence in male dogs using a percutaneous fluoroscopically assisted perineal approach.Journal of veterinary internal medicine · 2026Article
- Intraurethral cross-linked hyaluronic acid/dextranomer (DEXSUI®) injection versus mid-urethral sling for stress urinary incontinence: a comparative short-term outcome analysis.The Canadian journal of urology · 2026Article
- Functional hydrogel biomaterials for urological diagnosis and treatment-design strategies and application progress: a review.Journal of materials science. Materials in medicine · 2026Review
- Stress Urinary Incontinence Procedure Outcomes in the < 40-Year-Old Population: A Multicenter Study.International urogynecology journal · 2026Article
- The Impact of Treatment Setting on Periurethral Bulking.International urogynecology journal · 2026Article
- Effectiveness and Safety Profile of Urethral Bulking with BulkamidInternational urogynecology journal · 2025Article
- One-year outcomes of polyacrylamide hydrogel (Bulkamid) injection in women with stress and mixed urinary incontinence.World journal of urology · 2024Article
- Update on Urethral Bulking for Stress Urinary Incontinence in Women.Current urology reports · 2022Review
- Periurethral injection with polyacrylamide after previous TVT surgery.International urogynecology journal · 2022Article
- Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation.Frontiers in bioengineering and biotechnology · 2022Review
- Combination therapy with botulinum toxin and bulking agent-An efficient, sustainable, and safe method to treat elderly women with mixed urinary incontinence.Neurourology and urodynamics · 2021Article
- Urethral bulking agents: a retrospective review of primary versus salvage procedure outcomes.World journal of urology · 2021Article
- Seven-year efficacy and safety outcomes of Bulkamid for the treatment of stress urinary incontinence.Neurourology and urodynamics · 2021Article
- Regenerative medicine and injection therapies in stress urinary incontinence.Nature reviews. Urology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionPolyacrylamide hydrogel (PAHG, Bulkamid®) is a promising urethral bulking agent. This multicenter study was carried out to evaluate safety and efficacy of Bulkamid® for female stress and mixed urinary incontinence.
methodsSubmucosal injection of Bulkamid® was performed in 135 women with urinary incontinence (stress, 67; mixed, 68) followed for 12 months. Forty-seven had a reinjection (35%).
resultsAt 12 months, the subjective response rate was 66%. Incontinence episodes/24 h and urine leakage g/24 h decreased significantly (from 3.0 to 0.7 and 29 g to 4 g, respectively). Additionally, the median International Consultation on Incontinence Questionnaire score was reduced to approximately 50%, and the overall quality of life visual analogue scale score was decreased significantly (from 72 to 20). Efficacy was very similar between patients with stress and mixed incontinence. Thirty treatment-related adverse events were registered. The most frequent was urinary tract infection (n = 10). No polyacrylamide hydrogel-specific adverse events were seen.
conclusionsBulkamid® is an effective and safe bulking agent in women with stress or mixed incontinence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.