ReviewJournal of molecular neuroscience : MN2011
Trophic effects of PACAP on pancreatic islets: a mini-review.
Review in Journal of molecular neuroscience : MN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study.International journal of molecular sciences · 2021Article
- PACAP and PAC1 receptor expression in pancreatic ductal carcinoma.Oncology letters · 2019Article
- The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.Molecular metabolism · 2018Article
- A novel selective VPAC2 agonist peptide-conjugated chitosan modified selenium nanoparticles with enhanced anti-type 2 diabetes synergy effects.International journal of nanomedicine · 2017Article
- Distinct effects of dipeptidyl peptidase-4 inhibitor and glucagon-like peptide-1 receptor agonist on islet morphology and function.Endocrine · 2016Article
- Role of ZAC1 in transient neonatal diabetes mellitus and glucose metabolism.World journal of biological chemistry · 2015Review
- Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice.Biochemistry and biophysics reports · 2015Article
- Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications.International journal of endocrinology · 2015Review
- Molecular mechanisms underlying the Nephroprotective effects of PACAP in diabetes.Journal of molecular neuroscience : MN · 2014Article
- Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome.Genome research · 2013Article
- Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction.DNA and cell biology · 2013Review
- PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density.Frontiers in endocrinology · 2013Article
- PACAP is an endogenous protective factor-insights from PACAP-deficient mice.Journal of molecular neuroscience : MN · 2012Article
- Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in β cells.Journal of molecular neuroscience : MN · 2012Article
- Changes in PACAP immunoreactivity in human milk and presence of PAC1 receptor in mammary gland during lactation.Journal of molecular neuroscience : MN · 2012Article
- MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity.The Journal of clinical investigation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progressive beta-cell insufficiency in the pancreas is a hallmark of both types I and II diabetes, and agents that protect against beta-cell dysfunction are potential drug targets for diabetes mellitus. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a strong secretagogue of insulin from pancreatic islets and is suggested to be involved in physiological blood glucose homeostasis and the pathology of diabetes. Recent studies in genetically engineered animal models have shown that PACAP stimulates pancreatic functions, especially in cooperation with other regulatory factors including glucose. Furthermore, chronic activation of PACAP signaling regulates pancreatic islet mass in a context-dependent manner. Accumulating in vivo and in vitro evidence suggest that PACAP has trophic effects and regulates both proliferation and cell viability of beta-cells and thereby contributes to protection against diabetes. This review focuses on such trophic actions of PACAP on pancreatic beta-cells and discusses the pathophysiological significance of pancreatic PACAP, with the aim to provide information for future development of treatment for diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.