ArticleBlood2010
RH genotyping in a sickle cell disease patient contributing to hematopoietic stem cell transplantation donor selection and management.
Article in Blood, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia.Transfusion · 2018Trial
- Asian-type DEL among D-negative patients and donors in Malaysia can ease the demand for D-negative red cells and RhIG.Blood global hematology · 2025Article
- Transitioning a multiethnic donor pool from serologic D-negative to molecularly RHD-negative at a hospital-based blood donor service.Journal of translational medicine · 2025Article
- Integrated analyses reveal unexpected complex inversion and recombination in RH genes.Blood advances · 2024Article
- DNA Reference Reagents for Genotyping RH Variants.The Journal of molecular diagnostics : JMD · 2024Article
- Breakpoint regions of an RHD-CE(4-9)-D allele and a rare JK allele in a Pacific Islander individual.Blood transfusion = Trasfusione del sangue · 2024Article
- Rh flow cytometry: An updated methodology for D antigen density applied to weak D types 164 and 165.Transfusion · 2023Article
- Asian-type DEL (RHD*DEL1) with an allo-anti-D: A paradoxical observation in a healthy multiparous woman.Transfusion · 2023Article
- Transfusion support for a woman withImmunohematology · 2022Article
- Rh antibodies as a result of altered Rh epitopes on transfused red cells: a case series of seven Brazilian patients.Blood transfusion = Trasfusione del sangue · 2021Article
- Proceed with care: the "uncommon" serologic weak D phenotypes.Blood transfusion = Trasfusione del sangue · 2021Article
- Article
- First Korean Case of Partial DAnnals of laboratory medicine · 2020Article
- An outcome-based review of an accredited Specialist in Blood Banking (SBB) program: 25 years and counting.Immunohematology · 2020Review
- Red Cell Transfusions in the Genomics Era.Seminars in hematology · 2019Review
- Transfusion Support in Patients with Hematologic Disease: New and Novel Transfusion Modalities.Seminars in hematology · 2019Article
- Article
- Two large deletions extending beyond either end of the RHD gene and their red cell phenotypes.Journal of human genetics · 2018Article
- Immunohaematological complications in patients with sickle cell disease after haemopoietic progenitor cell transplantation: a prospective, single-centre, observational study.The Lancet. Haematology · 2017Observational
- Red cell genotyping precision medicine: a conference summary.Therapeutic advances in hematology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
African individuals harbor molecular RH variants, which permit alloantibody formation to high-prevalence Rh antigens after transfusions. Genotyping identifies such RH variants, which are often missed by serologic blood group typing. Comprehensive molecular blood group analysis using 3 genotyping platforms, nucleotide sequencing, and serologic evaluation was performed on a 7-year-old African male with sickle cell disease who developed an "e-like" antibody shortly after initiating monthly red blood cell (RBC) transfusions for silent stroke. Genotyping of the RH variant predicted a severe shortage of compatible RBCs for long-term transfusion support, which contributed to the decision for hematopoetic stem cell transplantation. RH genotyping confirmed the RH variant in the human leukocyte antigen-matched sibling donor. The patient's (C)ce(s) type 1 haplotype occurs in up to 11% of African American sickle cell disease patients; however, haplotype-matched RBCs were serologically incompatible. This case documents that blood unit selection should be based on genotype rather than one matching haplotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.