Evidence map›Paper›PMID 20644093›Full record

ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2010

Host factors and cancer progression: biobehavioral signaling pathways and interventions.

Susan K Lutgendorf, Anil K Sood, Michael H Antoni

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 2 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 2 syntheses or guidelines pooled it, 235 citations in OpenAlex.

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  13. Psychosocial telephone counseling for survivors of cervical cancer: results of a randomized biobehavioral trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015
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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Susan K LutgendorfSylvester Cancer Center, University of Miami, 5665 Ponce de Leon Blvd, 413 Fred C and Helen Donn Flipse Building, Coral Gables, FL 33146, USA.
Anil K Sood
Michael H Antoni
Sylvester Comprehensive Cancer Center · US

Funding

UNIVERSITY OF TEXAS MD ANDERSON SPORE IN OVARIAN CANCERP50CA083639 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C · 1999 to 2015
$33.0M
Ovarian Cancer: Mechanisms of Neuroendocrine RegulationR01CA109298 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2005 to 2017
$4.5M
FACILITATING POSITIVE ADAPTATION TO BREAST CANCERR01CA064710 · NCI · UNIVERSITY OF MIAMI CORAL GABLES · PI ANTONI, MICHAEL HOWARD · 1994 to 2010
$4.2M
Biobehavioral Influences and the Ovarian Tumor MicroenvironmentR01CA140933 · NCI · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K · 2009 to 2013
$2.8M
Tumor metastasis: Biobehavioral mechanismsR01CA110793 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2004 to 2009
$2.1M
Biobehavioral-Cytokine Interactions:Ovarian Cancer(RMI)R01CA104825 · NCI · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K · 2003 to 2007
$1.8M
Healing Touch, Immunity, and Fatigue in Breast CancerR21CA102515 · NCI · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K · 2003 to 2004
$443k
BIOBEHAVIORAL IMMUNE INTERACTIONS IN OVARIAN CANCERR21CA088293 · NCI · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K · 2000 to 2001
$398k
NCI NIH HHS P50 CA083639NCI NIH HHS R01 CA064710NCI NIH HHS R01 CA104825NCI NIH HHS R01 CA109298NCI NIH HHS R01 CA110793NCI NIH HHS R01 CA140933NCI NIH HHS R21 CA088293NCI NIH HHS R21 CA102515
6 · The paper itself

Abstract

Whereas evidence for the role of psychosocial factors in cancer initiation has been equivocal, support continues to grow for links between psychological factors such as stress, depression, and social isolation and progression of cancer. In vitro, in vivo, and clinical studies show that stress- related processes can impact pathways implicated in cancer progression, including immuno-regulation, angiogenesis, and invasion. Contributions of systemic factors, such as stress hormones to the crosstalk between tumor and stromal cells, appear to be critical in modulating downstream signaling pathways with important implications for disease progression. Inflammatory pathways may also be implicated in fatigue and other factors related to quality of life. Although substantial evidence supports a positive effect of psychosocial interventions on quality of life in cancer, the clinical evidence for efficacy of stress-modulating psychosocial interventions in slowing cancer progression remains inconclusive, and the biobehavioral mechanisms that might explain such effects are still being established. This article reviews research findings to date and outlines future avenues of research in this area.

Indexed as

Cell MovementDisease ProgressionHumansNeoplasm InvasivenessNeoplasmsNeovascularization, PhysiologicSignal TransductionStress, Psychological

Identifiers

PMID20644093
PMCPMC2940426
OpenAlexW2131832357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.