Evidence map›Paper›PMID 20644033›Full record

ArticleArchives of dermatology2010

Interstitial lung disease in classic and skin-predominant dermatomyositis: a retrospective study with screening recommendations.

Pamela A Morganroth, Mary Elizabeth Kreider, Joyce Okawa, Lynne Taylor, Victoria P Werth

Erratum issuedOpen access · bronzeAbstract readComparative Study
In one paragraph

Article in Archives of dermatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Cutaneous Manifestations of Dermatomyositis: a Comprehensive Review.Clinical reviews in allergy & immunology · 2017
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Pulmonary hypertension in polymyositis.Clinical rheumatology · 2015
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Amyopathic dermatomyositis complicated by pneumomediastinum.The Journal of clinical and aesthetic dermatology · 2013
    Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pamela A MorganrothDepartment of Dermatology, Hospital of the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Mary Elizabeth Kreider
Joyce Okawa
Lynne Taylor
Victoria P Werth
Philadelphia VA Medical Center · USHospital of the University of Pennsylvania · US

Funding

Penn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0M
PATIENT-ORIENTED RESEARCH IN SKIN AUTOMMUNE DISEASEK24AR002207 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI WERTH, VICTORIA P · 2001 to 2012
$1.3M
NIAMS NIH HHS 5T32-AR007465-26NIAMS NIH HHS K24 AR002207NIAMS NIH HHS K24-AR 02207NIAMS NIH HHS T32 AR007465
6 · The paper itself

Abstract

objectives(1) To determine the prevalence of interstitial lung disease (ILD) and isolated low diffusing capacity for carbon monoxide (DLCO) in a large cohort of outpatients with dermatomyositis. (2) To compare the pulmonary abnormalities of patients with classic dermatomyositis and those with skin-predominant dermatomyositis.

designRetrospective cohort study.

settingUniversity hospital outpatient dermatology referral center. Patients Medical records of 91 outpatients with adult-onset dermatomyositis seen between May 26, 2006, and May 25, 2009, were reviewed.

main outcome measuresPresence of ILD on thin-slice chest computed tomographic (CT) scans and DLCO.

resultsOf the 71 patients with dermatomyositis who had CT or DLCO data, 16 (23%; 95% confidence interval [CI], 13%-33%) had ILD as defined by CT results [corrected]. All patients with ILD had a reduced DLCO, and the ILD prevalence was not different between patients with skin-predominant dermatomyositis (10 of 35 [29% ]) and those with classic dermatomyositis (6 of 36 [17% ]) (P = .27). Eighteen of 71 patients with dermatomyositis (25%; 95% CI, 15%-36%) (7 of 35 [20%] with skin-predominant dermatomyositis; 11 of 36 [31%] with classic dermatomyositis; P = .41) had a low DLCO in the absence of CT findings showing ILD. The prevalence of malignant disease was higher in patients with classic dermatomyositis than in those with skin-predominant dermatomyositis (P = .02), and no patients with skin-predominant dermatomyositis had internal malignant disease.

conclusionsRadiologic ILD and isolated DLCO reductions, which may signify early ILD or pulmonary hypertension, are common in dermatology outpatients with both classic and skin-predominant dermatomyositis. Because DLCO testing is both inexpensive and sensitive for pulmonary disease, it may be appropriate to screen all patients with dermatomyositis with serial DLCO measurements and base further testing on DLCO results.

Indexed as

Practice Guidelines as TopicAdultDermatomyositisFemaleFollow-Up StudiesHumansLung Diseases, InterstitialMaleMass ScreeningMiddle AgedPrevalencePulmonary Diffusing CapacityRetrospective StudiesSeverity of Illness IndexTomography, X-Ray Computed

Identifiers

PMID20644033
PMCPMC3010864
OpenAlexW2074326165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.