Trial reportCirculation2010
Short- and medium-term outcomes after transcatheter pulmonary valve placement in the expanded multicenter US melody valve trial.
Trial report in Circulation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00740870 (Implantation of the Medtronic Melody Transcatheter Pulmonary Valve in Patients With Dysfunctional Right Ventricular Outflow Tract), which is not on this map. Cited by 122 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implantation of the Medtronic Melody Transcatheter Pulmonary Valve in Patients With Dysfunctional Right Ventricular Outflow Tract (RVOT) Conduits: A Feasibility Study
Who cites it
122 citing papers in PubMed, 570 citations in OpenAlex.
- Long-Term Outcomes After Melody Transcatheter Pulmonary Valve Replacement in the US Investigational Device Exemption Trial.Circulation. Cardiovascular interventions · 2022Trial
- Changes in speckle tracking echocardiography measures of ventricular function after percutaneous implantation of the Edwards SAPIEN transcatheter heart valve in the pulmonary position.Echocardiography (Mount Kisco, N.Y.) · 2015Trial
- Early echocardiographic changes after percutaneous implantation of the Edwards SAPIEN transcatheter heart valve in the pulmonary position.Echocardiography (Mount Kisco, N.Y.) · 2013Trial
- Acute Leaflet Dysfunction in Transcatheter Pulmonary Valves.JACC. Case reports · 2026Article
- Evaluation of the RESILIA tissue valve for pulmonary valve replacement: Early outcomes and hemodynamic performance.International journal of cardiology. Congenital heart disease · 2026Article
- Feasibility of 35-mm Balloon-Expandable Transcatheter Pulmonary Valve Implantation in Extra-Large Native Right Ventricular Outflow Tracts.JACC. Case reports · 2026Article
- The Initial Middle Eastern Experience With the Alterra Adaptive Pre-Stent: Single-Center Outcomes From Saudi Arabia.CJC pediatric and congenital heart disease · 2026Article
- Modified Melody Valve Surgical Implantation in Atrioventricular Position in Four Children Under Two Years of Age.Pediatric cardiology · 2026Article
- Evaluation of the Venus P-valve for transcatheter pulmonary valve replacement in patients with right ventricular outflow tract dysfunction.Future cardiology · 2026Review
- Pulmonary Valve Replacement: Update on Timing and Ventricular Remodelling.Journal of clinical medicine · 2026Review
- Lifelong Management of Right Ventricular Outflow Tract Dysfunction in Adults with Congenital Heart Disease.Methodist DeBakey cardiovascular journal · 2026Review
- Clinical outcomes of injectable and conventional pulmonary valve replacement in severe pulmonary regurgitation.Turkish journal of medical sciences · 2026Article
- Prevalence of Aspirin Resistance in Patients with Transcatheter Pulmonary Valve Replacement.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- A Novel Modification of the Melody Valve in a Short Right Ventricle-Pulmonary Artery Conduit: A Case Report.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract.Scientific reports · 2025Article
- Extended Rhythm Monitoring to Assess for Ventricular Arrhythmias After Transcatheter Pulmonary Valve Replacement With the Harmony Valve.Circulation. Cardiovascular interventions · 2025Article
- Early-term results of percutaneous pulmonary valve implantation (valve-in-valve) in dysfunctional bioprosthetic valves in pulmonary position.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Transcatheter Pulmonary Valve Replacement (TPVR): A Saudi Consensus Statement.Journal of the Saudi Heart Association · 2025Article
- Percutaneous pulmonary valve implantation guided by three-dimensional rotational angiography.International journal of cardiology. Congenital heart disease · 2024Article
- Melody transcatheter pulmonary valve replacement: a single-center case series in Southeast Asia.BMC cardiovascular disorders · 2024Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundTranscatheter pulmonary valve placement is an emerging therapy for pulmonary regurgitation and right ventricular outflow tract obstruction in selected patients. The Melody valve was recently approved in the United States for placement in dysfunctional right ventricular outflow tract conduits. METHODS AND
resultsFrom January 2007 to August 2009, 136 patients (median age, 19 years) underwent catheterization for intended Melody valve implantation at 5 centers. Implantation was attempted in 124 patients; in the other 12, transcatheter pulmonary valve placement was not attempted because of the risk of coronary artery compression (n=6) or other clinical or protocol contraindications. There was 1 death from intracranial hemorrhage after coronary artery dissection, and 1 valve was explanted after conduit rupture. The median peak right ventricular outflow tract gradient was 37 mm Hg before implantation and 12 mm Hg immediately after implantation. Before implantation, pulmonary regurgitation was moderate or severe in 92 patients (81% with data); no patient had more than mild pulmonary regurgitation early after implantation or during follow-up (>or=1 year in 65 patients). Freedom from diagnosis of stent fracture was 77.8+/-4.3% at 14 months. Freedom from Melody valve dysfunction or reintervention was 93.5+/-2.4% at 1 year. A higher right ventricular outflow tract gradient at discharge (P=0.003) and younger age (P=0.01) were associated with shorter freedom from dysfunction.
conclusionsIn this updated report from the multicenter US Melody valve trial, we demonstrated an ongoing high rate of procedural success and encouraging short-term valve function. All reinterventions in this series were for right ventricular outflow tract obstruction, highlighting the importance of patient selection, adequate relief of obstruction, and measures to prevent and manage stent fracture. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00740870.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.