ArticleInfection and immunity2010
An ABC transporter and a TonB ortholog contribute to Helicobacter mustelae nickel and cobalt acquisition.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Comparative genomic analysis of nickel homeostasis in cable bacteria.BMC genomics · 2024Article
- Cytotoxic effects and comparative analysis of Ni ion uptake by osteoarthritic and physiological osteoblasts.Scientific reports · 2024Article
- Evolutionary engineering and molecular characterization of cobalt-resistantFrontiers in microbiology · 2024Article
- The Effects of Vitamins and Micronutrients onJournal of immunology research · 2022Review
- Metal homeostasis in pathogenic Epsilonproteobacteria: mechanisms of acquisition, efflux, and regulation.Metallomics : integrated biometal science · 2021Review
- The requirement for cobalt in vitamin BBiochimica et biophysica acta. Molecular cell research · 2021Review
- Ni(II) Interactions in BorealFrontiers in microbiology · 2019Article
- Zinc ions have a potential to attenuate both Ni ion uptake and Ni ion-induced inflammation.Scientific reports · 2018Article
- Characterization in Helicobacter pylori of a Nickel Transporter Essential for Colonization That Was Acquired during Evolution by Gastric Helicobacter Species.PLoS pathogens · 2016Article
- Nutrition and Helicobacter pylori: Host Diet and Nutritional Immunity Influence Bacterial Virulence and Disease Outcome.Gastroenterology research and practice · 2016Review
- Metalloregulation of Helicobacter pylori physiology and pathogenesis.Frontiers in microbiology · 2015Review
- Helicobacter hepaticus NikR controls urease and hydrogenase activities via the NikABDE and HH0418 putative nickel import proteins.Microbiology (Reading, England) · 2013Article
- Common themes and unique proteins for the uptake and trafficking of nickel, a metal essential for the virulence of Helicobacter pylori.Frontiers in cellular and infection microbiology · 2013Review
- An ABC-type cobalt transport system is essential for growth of Sinorhizobium meliloti at trace metal concentrations.Journal of bacteriology · 2011Article
- RcnB is a periplasmic protein essential for maintaining intracellular Ni and Co concentrations in Escherichia coli.Journal of bacteriology · 2011Article
- Mapping the regulon of Vibrio cholerae ferric uptake regulator expands its known network of gene regulation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The genomes of Helicobacter species colonizing the mammalian gastric mucosa (like Helicobacter pylori) contain a large number of genes annotated as iron acquisition genes but only few nickel acquisition genes, which contrasts with the central position of nickel in the urease-mediated acid resistance of these gastric pathogens. In this study we have investigated the predicted iron and nickel acquisition systems of the ferret pathogen Helicobacter mustelae. The expression of the outer membrane protein-encoding frpB2 gene was iron and Fur repressed, whereas the expression of the ABC transporter genes fecD and ceuE was iron and Fur independent. The inactivation of the two tonB genes showed that TonB1 is required for heme utilization, whereas the absence of TonB2 only marginally affected iron-dependent growth but led to reduced cellular nickel content and urease activity. The inactivation of the fecD and ceuE ABC transporter genes did not affect iron levels but resulted in significantly reduced urease activity and cellular nickel content. Surprisingly, the inactivation of the nixA nickel transporter gene affected cellular nickel content and urease activity only when combined with the inactivation of other nickel acquisition genes, like fecD or ceuE. The FecDE ABC transporter is not specific for nickel, since an fecD mutant also showed reduced cellular cobalt levels and increased cobalt resistance. We conclude that the H. mustelae fecDE and ceuE genes encode an ABC transporter involved in nickel and cobalt acquisition, which works independently of the nickel transporter NixA, while TonB2 is required primarily for nickel acquisition, with TonB1 being required for heme utilization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.