ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2010
Genetic linkage and natural selection.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Genomic sequencing reveals convergent adaptation during experimental evolution in two budding yeast species.Communications biology · 2024Article
- Hiding in plain sight: Genome-wide recombination and a dynamic accessory genome drive diversity inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Population-level deep sequencing reveals the interplay of clonal and sexual reproduction in the fungal wheat pathogenMicrobial genomics · 2021Article
- Seasonal changes in recombination characteristics in a natural population of Drosophila melanogaster.Heredity · 2021Article
- Leaf anatomy is not correlated to CAM function in a C3+CAM hybrid species, Yucca gloriosa.Annals of botany · 2021Article
- Drivers of linkage disequilibrium across a species' geographic range.PLoS genetics · 2021Article
- How Much DoesGenetics · 2020Article
- The determinants of genetic diversity in butterflies.Nature communications · 2019Article
- The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection.Genetics · 2019Article
- Growth factor gene IGF1 is associated with bill size in the black-bellied seedcracker Pyrenestes ostrinus.Nature communications · 2018Article
- Modularity of genes involved in local adaptation to climate despite physical linkage.Genome biology · 2018Article
- Characterisation of pathogen-specific regions and novel effector candidates in Fusarium oxysporum f. sp. cepae.Scientific reports · 2018Article
- Article
- High mutation rates limit evolutionary adaptation in Escherichia coli.PLoS genetics · 2018Article
- Weak Epistasis May Drive Adaptation in Recombining Bacteria.Genetics · 2018Article
- Clonal interference can cause wavelet-like oscillations of multilocus linkage disequilibrium.Journal of the Royal Society, Interface · 2018Article
- Haldane and modern evolutionary genetics.Journal of genetics · 2017Article
- The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution.Genome biology and evolution · 2017Article
- Estimating the parameters of background selection and selective sweeps inProceedings of the National Academy of Sciences of the United States of America · 2017Article
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Abstract
The prevalence of recombination in eukaryotes poses one of the most puzzling questions in biology. The most compelling general explanation is that recombination facilitates selection by breaking down the negative associations generated by random drift (i.e. Hill-Robertson interference, HRI). I classify the effects of HRI owing to: deleterious mutation, balancing selection and selective sweeps on: neutral diversity, rates of adaptation and the mutation load. These effects are mediated primarily by the density of deleterious mutations and of selective sweeps. Sequence polymorphism and divergence suggest that these rates may be high enough to cause significant interference even in genomic regions of high recombination. However, neither seems able to generate enough variance in fitness to select strongly for high rates of recombination. It is plausible that spatial and temporal fluctuations in selection generate much more fitness variance, and hence selection for recombination, than can be explained by uniformly deleterious mutations or species-wide selective sweeps.
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