ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2010
Experimental evolution of viruses: Microviridae as a model system.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- CApEsid biOfilm: a suggested pipeline for clinical phage microbiology for biofilm infections based on comparative method study.Scientific reports · 2026Article
- Single capsid mutations modulating phage adsorption, persistence, and plaque morphology shape evolutionary trajectories in ΦX174.Virus evolution · 2026Article
- Mystique, a broad host range Acinetobacter phage, reveals the impact of culturing conditions on phage isolation and infectivity.PLoS pathogens · 2025Article
- The untapped potential of phage model systems as therapeutic agents.Virus evolution · 2024Article
- Best Practices in Microbial Experimental Evolution.Journal of molecular evolution · 2023Article
- The roles of divergent and parallel molecular evolution contributing to thermal adaptive strategies in trees.Plant, cell & environment · 2022Article
- Bacterial evolution during human infection: Adapt and live or adapt and die.PLoS pathogens · 2021Review
- Article
- Saturation Mutagenesis Genome Engineering of Infective ΦX174 BacteriophageACS synthetic biology · 2020Article
- Microbial Experimental Evolution - a proving ground for evolutionary theory and a tool for discovery.EMBO reports · 2019Review
- Biophysical Spandrels form a Hot-Spot for Kosmotropic Mutations in Bacteriophage Thermal Adaptation.Journal of molecular evolution · 2019Article
- Review
- Diversity and Distribution Characteristics of Viruses in Soils of a Marine-Terrestrial Ecotone in East China.Microbial ecology · 2018Article
- Constrained evolvability of interferon suppression in an RNA virus.Scientific reports · 2016Article
- Genetically Determined Variation in Lysis Time Variance in the Bacteriophage φX174.G3 (Bethesda, Md.) · 2016Article
- Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold.Frontiers in microbiology · 2015Review
- Experimental evolution of an RNA virus in cells with innate immunity defects.Virus evolution · 2015Article
- A new Microviridae phage isolated from a failed biotechnological process driven by Escherichia coli.Applied and environmental microbiology · 2014Article
- Fitness benefits of low infectivity in a spatially structured population of bacteriophages.Proceedings. Biological sciences · 2014Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
phiX174 was developed as a model system for experimental studies of evolution because of its small genome size and ease of cultivation. It has been used extensively to address statistical questions about the dynamics of adaptive evolution. Molecular changes seen during experimental evolution of phiX174 under a variety of conditions were compiled from 10 experiments comprising 58 lineages, where whole genomes were sequenced. A total of 667 substitutions was seen. Parallel evolution was rampant, with over 50 per cent of substitutions occurring at sites with three or more events. Comparisons of experimentally evolved sites to variation seen among wild phage suggest that at least some of the adaptive mechanisms seen in the laboratory are relevant to adaptation in nature. Elucidation of these mechanisms is aided by the availability of capsid and pro-capsid structures for phiX174 and builds on years of genetic studies of the phage life history.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.