ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2010
Divergence, demography and gene loss along the human lineage.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- What Fraction of Duplicates Observed in Recently Sequenced Genomes Is Segregating and Destined to Fail to Fix?Genome biology and evolution · 2015Article
- CHRFAM7A: a human-specific α7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- A human-specific allelic group of the MHC DRB1 gene in primates.Journal of physiological anthropology · 2014Article
- A scan for human-specific relaxation of negative selection reveals unexpected polymorphism in proteasome genes.Molecular biology and evolution · 2013Article
- Great ape genomics.ILAR journal · 2013Review
- Evolutionary constraints in the β-globin cluster: the signature of purifying selection at the δ-globin (HBD) locus and its role in developmental gene regulation.Genome biology and evolution · 2013Article
- Evolution of genetic and genomic features unique to the human lineage.Nature reviews. Genetics · 2012Review
- Exploring the potential relevance of human-specific genes to complex disease.Human genomics · 2011Review
- Genetics and the causes of evolution: 150 years of progress since Darwin.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Genomic DNA sequences are an irreplaceable source for reconstructing the vanished past of living organisms. Based on updated sequence data, this paper summarizes our studies on species divergence time, ancient population size and functional loss of genes in the primate lineage leading to modern humans (Homo sapiens sapiens). The inter- and intraspecific comparisons of DNA sequences suggest that the human lineage experienced a rather severe bottleneck in the Middle Pleistocene, throughout which period the subdivided African population played a predominant role in shaping the genetic architecture of modern humans. Also, published and newly identified human-specific pseudogenes (HSPs) are enumerated in order to infer their significance for human evolution. Of the 121 candidate genes obtained, authentic HSPs turn out to comprise only 25 olfactory receptor genes, four T cell receptor genes and nine other genes. The fixation of HSPs has been too rare over the past 6-7 Myr to account for species differences between humans and chimpanzees.
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