ArticleSexually transmitted infections2011
Estimating the risk of HIV transmission from homosexual men receiving treatment to their HIV-uninfected partners.
Article in Sexually transmitted infections, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.The Cochrane database of systematic reviews · 2013Pooled it
- Trial
- Changes in high-risk sexual behavior, HIV and other STI testing, and PrEP use during the COVID-19 pandemic in a longitudinal cohort of adolescent men who have sex with men 13 to 18 years old in the United States.AIDS and behavior · 2023Article
- An Examination of Gay Couples' Motivations to Use (or Forego) Pre-exposure Prophylaxis Expressed During Couples HIV Testing and Counseling (CHTC) Sessions.Prevention science : the official journal of the Society for Prevention Research · 2019Article
- Relationship characteristics and HIV transmission risk in same-sex male couples in HIV serodiscordant relationships.Archives of sexual behavior · 2014Article
- Personal or relational? Examining sexual health in the context of HIV serodiscordant same-sex male couples.AIDS and behavior · 2014Article
- Sexual risk for HIV among gay male couples: a longitudinal study of the impact of relationship dynamics.Archives of sexual behavior · 2014Article
- Past present: Relationship dynamics may differ among discordant gay male couples depending on HIV infection history.Journal of gay & lesbian social services · 2013Article
- Individual-based simulation models of HIV transmission: reporting quality and recommendations.PloS one · 2013Review
- Is back-projection methodology still relevant for estimating HIV incidence from national surveillance data?The open AIDS journal · 2012Article
- Article
- Epistemic fault lines in biomedical and social approaches to HIV prevention.Journal of the International AIDS Society · 2011Review
- Modelling the impact of antiretroviral therapy on the epidemic of HIV.Current HIV research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo determine how the risk of HIV transmission from homosexual men receiving antiretroviral treatment is related to patterns of patient monitoring and condom use.
methodsA stochastic mathematical simulation model was developed of cohorts of men in the Netherlands who have sex with men (MSM), defining the parameters of the model using observational cohort data. The model incorporates viral load trends during first-line treatment, patient monitoring and different scenarios for the way in which condom use may depend on recent viral load measurements. The model does not include the effect of sexually transmitted infections on HIV transmission.
resultsFor MSM receiving treatment, the risk of transmitting HIV to their long-term partner is 22% (uncertainty interval: 9-37%) if condoms are never used. With incomplete use (in 30% of sex acts) the risk is reduced slightly, to 17% (7-29%). However, the risk is as low as 3% (0.2-8%) when men receiving treatment use condoms only 6 months beyond their last undetectable viral load measurement. The risk is further reduced when 3 months is the time period beyond which condoms are used.
conclusionsWhen condom use by HIV-infected men receiving combination treatment with antiretroviral agents is based on their last viral load measurement, the transmission risk is much lower than with incomplete condom use. The key message for patients is that although always using condoms during treatment is the best way to protect partners from the risk of HIV transmission, when such use cannot be achieved, the second best strategy is to use condoms whenever the last undetectable viral load was measured more than 3 months ago.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.