ArticleAmerican journal of ophthalmology2010
Plus disease in retinopathy of prematurity: quantitative analysis of vascular change.
Article in American journal of ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Trial
- Prediction of retinopathy of prematurity using machine learning models.Pediatric research · 2026Article
- Does field of view matter? Assessing its impact on Plus disease diagnosis in retinopathy of prematurity.International journal of retina and vitreous · 2025Article
- Retinopathy of Prematurity and Risk of Structural Brain Abnormalities on Magnetic Resonance Imaging at Term Among Infants Born at Less Than or Equal to 32 Weeks of Gestation.The Journal of pediatrics · 2025Article
- Computer-aided detection of retinopathy of prematurity severity assessment via vessel tortuosity measurement in preterm infants' fundus images.Eye (London, England) · 2024Article
- Variability in Plus Disease Diagnosis using Single and Serial Images.Ophthalmology. Retina · 2022Article
- Plus Disease in Retinopathy of Prematurity: Convolutional Neural Network Performance Using a Combined Neural Network and Feature Extraction Approach.Translational vision science & technology · 2020Article
- Retinopathy of Prematurity-assist: Novel Software for Detecting Plus Disease.Korean journal of ophthalmology : KJO · 2017Article
- Plus Disease in Retinopathy of Prematurity: Diagnostic Trends in 2016 Versus 2007.American journal of ophthalmology · 2017Article
- Computer-aided diagnosis of retinopathy in retinal fundus images of preterm infants via quantification of vascular tortuosity.Journal of medical imaging (Bellingham, Wash.) · 2016Article
- Dealing with inter-expert variability in retinopathy of prematurity: A machine learning approach.Computer methods and programs in biomedicine · 2015Article
- Aggressive posterior retinopathy of prematurity: a pilot study of quantitative analysis of vascular features.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Plus disease diagnosis in retinopathy of prematurity: vascular tortuosity as a function of distance from optic disk.Retina (Philadelphia, Pa.) · 2013Article
- A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease.Investigative ophthalmology & visual science · 2013Article
- Plus disease in retinopathy of prematurity: qualitative analysis of diagnostic process by experts.JAMA ophthalmology · 2013Article
- Image analysis for retinopathy of prematurity: where are we headed?Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2012Article
- Plus disease in retinopathy of prematurity: diagnostic impact of field of view.Retina (Philadelphia, Pa.) · 2012Article
- Evaluation of vascular disease progression in retinopathy of prematurity using static and dynamic retinal images.American journal of ophthalmology · 2012Article
- Computer-based image analysis for plus disease diagnosis in retinopathy of prematurity.Journal of pediatric ophthalmology and strabismusReview
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeTo examine the relationship between rate of vascular change and plus disease diagnosis.
designRetrospective observational case-control study.
methodsWide-angle images were taken bilaterally from 37 infants at 31 to 33 weeks and 35 to 37 weeks postmenstrual age (PMA). The semi-automated Retinal Image multiScale Analysis system was used to measure parameters for all arteries and veins: integrated curvature, diameter, and tortuosity index. A reference standard diagnosis (plus vs not plus) was defined for each eye by consensus of 5 experts at 35 to 37 weeks PMA. Weekly rate of change in parameters was compared in eyes with plus vs not plus disease. Receiver operating characteristic area under the curve (AUC) was calculated for plus disease detection based on 1) weekly rates of parameter change between 31 to 33 weeks and 35 to 37 weeks PMA and 2) parameter values at 35 to 37 weeks only.
resultsWeekly rates of change in all venous parameters were significantly different in eyes with plus vs not plus disease, particularly for tortuosity index (P < .0004) and diameter (P = .018). Using weekly rate of change, AUC for plus disease detection was highest for venous tortuosity index (0.819) and venous diameter (0.712). Using the 35 to 37-week PMA image only, AUC was highest for venous integrated curvature (0.952) and diameter (0.789).
conclusionRate of change in venous, but not arterial, parameters is correlated with plus disease development in this data set. This did not appear to contribute information beyond analysis of an image at 35 to 37 weeks PMA only.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.