ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2010
Immune therapy in autism: historical experience and future directions with immunomodulatory therapy.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Safety and Observations from a Placebo-Controlled, Crossover Study to Assess Use of Autologous Umbilical Cord Blood Stem Cells to Improve Symptoms in Children with Autism.Stem cells translational medicine · 2018Trial
- Effect of prednisolone on language function in children with autistic spectrum disorder: a randomized clinical trial.Jornal de pediatriaTrial
- Cognitive inflexibility and immunome biomarkers in children with autism spectrum disorder.Neuroscience applied · 2024Article
- Higher Levels of Galectin-1 and Galectin-3 in Young Subjects with Autism Spectrum Disorder Compared to Unaffected Siblings and Healthy Controls.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Chemical Modulators for Targeting Autism Spectrum Disorders: From Bench to Clinic.Molecules (Basel, Switzerland) · 2022Review
- Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders.International journal of molecular sciences · 2020Review
- Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?Frontiers in pharmacology · 2020Review
- Beyond the brain: A multi-system inflammatory subtype of autism spectrum disorder.Psychopharmacology · 2019Review
- Characterizing the Interplay Between Autism Spectrum Disorder and Comorbid Medical Conditions: An Integrative Review.Frontiers in psychiatry · 2018Review
- Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders.Translational psychiatry · 2016Review
- Corticosteroid therapy in regressive autism: Preliminary findings from a retrospective study.BMC medicine · 2014Article
- Corticosteroid therapy in regressive autism: a retrospective study of effects on the Frequency Modulated Auditory Evoked Response (FMAER), language, and behavior.BMC neurology · 2014Article
- Brain-reactive antibodies and disease.Annual review of immunology · 2013Review
- Microglia in the cerebral cortex in autism.Journal of autism and developmental disorders · 2012Article
- Perinatal stress, brain inflammation and risk of autism-review and proposal.BMC pediatrics · 2012Review
- Identification of autoimmune gene signatures in autism.Translational psychiatry · 2011Article
- Developing a Deeper Understanding of Autism: Connecting Knowledge through Literature Mining.Autism research and treatment · 2011Article
- Role of autoimmunity in Neuronal damage in children with Autism spectrum disorder.Pakistan journal of medical sciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism affects 1 in 110 new births, and it has no single etiology with uniform agreement. This has a significant impact on the quality of life for individuals who have been diagnosed with autism. Although autism has a spectrum quality with a shared diagnosis, it presents a uniquely different clinical appearance in each individual. Recent research of suspected immunological factors have provided more support for a probable immunological process or for processes that may play a role in the acquisition of an autistic condition. These factors include prenatal, genetic, and postnatal findings, as well as the discovery of a dysfunctional chronic pro-inflammatory state in brain tissue and cerebrospinal fluid in subsets of autistic patients. These findings offer new theories that may lead to the development of disease modification or preventative therapeutic options in the near future. This article reviews prenatal, genetic, and observed immune aspects of the autism condition that may be risk factors in the presentation of the autistic clinical phenotype. Historical immune interventions in autism are reviewed and potential new therapies and interventions are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.