Evidence map›Paper›PMID 20643311›Full record

ReviewJournal of the American Academy of Child and Adolescent Psychiatry2010

Imaging-genetics applications in child psychiatry.

Daniel S Pine, Monique Ernst, Ellen Leibenluft

Abstract readReview
In one paragraph

Review in Journal of the American Academy of Child and Adolescent Psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Depressive Symptoms Among Children and Adolescents in China: A Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Pooled it
  2. Review
  3. Loss aversion and 5HTT gene variants in adolescent anxiety.Developmental cognitive neuroscience · 2014
    Article
  4. Review
  5. Article
  6. Depression in adolescence.Lancet (London, England) · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel S PineNational Institute of Mental Health Intramural Research Program, Mood and Anxiety Disorders Program, Bethesda, MD 20892-2670, USA. daniel.pine@nih.gov
Monique Ernst
Ellen Leibenluft

Funding

The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZIAMH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2017
$10.8M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZ01MH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2000 to 2008
$3.1M
Fmri Studies Of Emotional DevelopmentZIAMH002780 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2011
$2.7M
Intramural NIH HHS Z01 MH002778
6 · The paper itself

Abstract

objectiveTo place imaging-genetics research in the context of child psychiatry.

methodA conceptual overview is provided, followed by discussion of specific research examples.

resultsImaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase enzyme. Work is then described on phenotype selection in imaging genetics.

conclusionsChild psychiatry applications of imaging genetics are only beginning to emerge. The approach holds promise for advancing understandings of pathophysiology and therapeutics.

Indexed as

Magnetic Resonance ImagingMagnetic Resonance SpectroscopyAdolescentAnimalsBrainChildGenetic Predisposition to DiseaseGenotypeHumansMental DisordersMonoamine OxidasePhenotypePolymorphism, GeneticSerotonin Plasma Membrane Transport ProteinsMonoamine OxidaseSerotonin Plasma Membrane Transport Proteins

Identifiers

PMID20643311
PMCPMC2997350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.