ReviewCritical care clinics2010
Can we protect the gut in critical illness? The role of growth factors and other novel approaches.
Review in Critical care clinics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Indole-3-carboxaldehyde fromGut microbes · 2026Article
- Associations of clinical indexes and prognosis with gut-vascular barrier damage in patients with intestinal obstruction.World journal of gastrointestinal surgery · 2025Article
- Protein modification by short-chain fatty acid metabolites in sepsis: a comprehensive review.Frontiers in immunology · 2023Review
- Potential role of gut microbiota in prostate cancer: immunity, metabolites, pathways of action?Frontiers in oncology · 2023Review
- Hepatorenal syndrome in acute-on-chronic liver failure with acute kidney injury: more questions requiring discussion.Gastroenterology report · 2021Review
- Gut-liver crosstalk in sepsis-induced liver injury.Critical care (London, England) · 2020Review
- Gut-kidney crosstalk in septic acute kidney injury.Critical care (London, England) · 2018Review
- Redefining the gut as the motor of critical illness.Trends in molecular medicine · 2014Review
- Extracellular ATP drives systemic inflammation, tissue damage and mortality.Cell death & disease · 2014Article
- Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice.PloS one · 2014Article
- Epidermal growth factor promotes proliferation and improves restoration after intestinal ischemia-reperfusion injury in rats.Inflammation · 2013Article
- The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis.Seminars in pediatric surgery · 2013Review
- Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis.PloS one · 2013Article
- The endogenous bacteria alter gut epithelial apoptosis and decrease mortality following Pseudomonas aeruginosa pneumonia.Shock (Augusta, Ga.) · 2012Article
- Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumonia.Shock (Augusta, Ga.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The intestine plays a central role in the pathophysiology of critical illness and is frequently called the "motor" of the systemic inflammatory response. Perturbations to the intestinal barrier can lead to distant organ damage and multiple organ failure. Therefore, identifying ways to preserve intestinal integrity may be of paramount importance. Growth factors and other peptides have emerged as potential tools for modulation of intestinal inflammation and repair due to their roles in cellular proliferation, differentiation, migration, and survival. This review examines the involvement of growth factors and other peptides in intestinal epithelial repair during critical illness and their potential use as therapeutic targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.