ArticleGenomics2010
Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping.
Article in Genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Reflections on the Human Genome Diversity Project: a conversation with Marcus W. Feldman, Henry T. Greely, and Mary-Claire King.Genetics · 2026Article
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- Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal.Psychological medicine · 2024Article
- Typological thinking in human genomics research contributes to the production and prominence of scientific racism.Frontiers in genetics · 2024Article
- Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk.Translational psychiatry · 2022Article
- Whole-Genome Sequencing and Genomic Variant Analysis of Kazakh Individuals.Frontiers in genetics · 2022Article
- The Simons Genome Diversity Project: A Global Analysis of Mobile Element Diversity.Genome biology and evolution · 2020Article
- Genetic Landscapes Reveal How Human Genetic Diversity Aligns with Geography.Molecular biology and evolution · 2020Article
- Reconstructing an African haploid genome from the 18th century.Nature genetics · 2018Article
- Reconstructing human population history from dental phenotypes.Scientific reports · 2017Article
- LASER server: ancestry tracing with genotypes or sequence reads.Bioinformatics (Oxford, England) · 2017Article
- Characterising private and shared signatures of positive selection in 37 Asian populations.European journal of human genetics : EJHG · 2017Article
- DNA methylation as a putative mechanism for reduced dendritic spine density in the superior temporal gyrus of subjects with schizophrenia.Translational psychiatry · 2017Article
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- Exploratory Item Classification Via Spectral Graph Clustering.Applied psychological measurement · 2017Article
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- Visualizing spatial population structure with estimated effective migration surfaces.Nature genetics · 2016Article
- BMD Loci Contribute to Ethnic and Developmental Differences in Skeletal Fragility across Populations: Assessment of Evolutionary Selection Pressures.Molecular biology and evolution · 2015Article
- Genomic copy number variation in Mus musculus.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
High-throughput genotyping data are useful for making inferences about human evolutionary history. However, the populations sampled to date are unevenly distributed, and some areas (e.g., South and Central Asia) have rarely been sampled in large-scale studies. To assess human genetic variation more evenly, we sampled 296 individuals from 13 worldwide populations that are not covered by previous studies. By combining these samples with a data set from our laboratory and the HapMap II samples, we assembled a final dataset of ~250,000 SNPs in 850 individuals from 40 populations. With more uniform sampling, the estimate of global genetic differentiation (F(ST)) substantially decreases from ~16% with the HapMap II samples to ~11%. A panel of copy number variations typed in the same populations shows patterns of diversity similar to the SNP data, with highest diversity in African populations. This unique sample collection also permits new inferences about human evolutionary history. The comparison of haplotype variation among populations supports a single out-of-Africa migration event and suggests that the founding population of Eurasia may have been relatively large but isolated from Africans for a period of time. We also found a substantial affinity between populations from central Asia (Kyrgyzstani and Mongolian Buryat) and America, suggesting a central Asian contribution to New World founder populations.
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