ArticleBiophysical journal2010
Mechanisms of capsid assembly around a polymer.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Modeling the Phase Equilibria of Associating Polymers in Porous Media with Respect to Chromatographic Applications.Polymers · 2022Article
- Polyelectrolyte Encapsulation and Confinement within Protein Cage-Inspired Nanocompartments.Pharmaceutics · 2021Review
- Real-Time Assembly of Viruslike Nucleocapsids Elucidated at the Single-Particle Level.Nano letters · 2019Article
- RNA-Mediated Virus Assembly: Mechanisms and Consequences for Viral Evolution and Therapy.Annual review of biophysics · 2019Review
- Defects and Chirality in the Nanoparticle-Directed Assembly of Spherocylindrical Shells of Virus Coat Proteins.ACS nano · 2018Article
- Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery.Molecular therapy. Nucleic acids · 2017Article
- Single Particle Observation of SV40 VP1 Polyanion-Induced Assembly Shows That Substrate Size and Structure Modulate Capsid Geometry.ACS chemical biology · 2017Article
- Computational virology: From the inside out.Biochimica et biophysica acta · 2016Review
- Article
- Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2.Journal of molecular biology · 2016Article
- The Role of Packaging Sites in Efficient and Specific Virus Assembly.Journal of molecular biology · 2015Article
- Mechanisms of virus assembly.Annual review of physical chemistry · 2015Review
- Simulations show that virus assembly and budding are facilitated by membrane microdomains.Biophysical journal · 2015Article
- Pathways for virus assembly around nucleic acids.Journal of molecular biology · 2014Article
- Solving a Levinthal's paradox for virus assembly identifies a unique antiviral strategy.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Scaffold properties are a key determinant of the size and shape of self-assembled virus-derived particles.ACS chemical biology · 2013Article
- Article
- To build a virus on a nucleic acid substrate.Biophysical journal · 2013Article
- Mechanical and assembly units of viral capsids identified via quasi-rigid domain decomposition.PLoS computational biology · 2013Article
- Density functional theory for encapsidated polyelectrolytes: a comparison with Monte Carlo simulation.The Journal of chemical physics · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Capsids of many viruses assemble around nucleic acids or other polymers. Understanding how the properties of the packaged polymer affect the assembly process could promote biomedical efforts to prevent viral assembly or nanomaterials applications that exploit assembly. To this end, we simulate on a lattice the dynamical assembly of closed, hollow shells composed of several hundred to 1000 subunits, around a flexible polymer. We find that assembly is most efficient at an optimum polymer length that scales with the surface area of the capsid; polymers that are significantly longer than optimal often lead to partial-capsids with unpackaged polymer "tails" or a competition between multiple partial-capsids attached to a single polymer. These predictions can be tested with bulk experiments in which capsid proteins assemble around homopolymeric RNA or synthetic polyelectrolytes. We also find that the polymer can increase the net rate of subunit accretion to a growing capsid both by stabilizing the addition of new subunits and by enhancing the incoming flux of subunits; the effects of these processes may be distinguishable with experiments that monitor the assembly of individual capsids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.