ArticleBiophysical journal2010
Implication of sphingomyelin/ceramide molar ratio on the biological activity of sphingomyelinase.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Adipose tissue ceramides: emerging lipid components of extracellular vesicles and their influence on metabolic dysregulation.Frontiers in endocrinology · 2026Review
- Sphingomyelinase-Mediated Multitimescale Clustering of Ganglioside GM1 in Heterogeneous Lipid Membranes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Endogenous cortisol excess confers a unique lipid signature and metabolic network.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Ceramides in Metabolism: Key Lipotoxic Players.Annual review of physiology · 2021Review
- Hydrologic variability governs population dynamics of a vulnerable amphibian in an arid environment.PloS one · 2015Article
- Insights into sphingolipid miscibility: separate observation of sphingomyelin and ceramide N-acyl chain melting.Biophysical journal · 2012Article
- Use of X-ray scattering to aid the design and delivery of membrane-active drugs.European biophysics journal : EBJ · 2012Review
- Lipid sorting by ceramide and the consequences for membrane proteins.Biophysical journal · 2012Article
- Ceramides as modulators of cellular and whole-body metabolism.The Journal of clinical investigation · 2011Review
- Stable and unstable lipid domains in ceramide-containing membranes.Biophysical journal · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sphingolipid signaling plays an important, yet not fully understood, role in diverse aspects of cellular life. Sphingomyelinase is a major enzyme in these signaling pathways, catalyzing hydrolysis of sphingomyelin to ceramide and phosphocholine. To address the related membrane dynamical structural changes and their feedback to enzyme activity, we have studied the effect of enzymatically generated ceramide in situ on the properties of a well-defined lipid model system. We found a gel-phase formation that was about four times faster than ceramide generation due to ceramide-sphingomyelin pairing. The gel-phase formation slowed down when the ceramide molar ratios exceeded those of sphingomyelin and stopped just at the solubility limit of ceramide, due to unfavorable pairwise interactions of ceramide with itself and with monounsaturated phosphatidylcholine. A remarkable correlation to in vitro experiments suggests a regulation of sphingomyelinase activity based on the sphingomyelin/ceramide molar ratio.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.