ArticleJournal of translational medicine2010
Effective knowledge management in translational medicine.
Article in Journal of translational medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014.American journal of respiratory and critical care medicine · 2015Pooled it
- Transforming research and clinical knowledge in traumatic brain injury pilot: multicenter implementation of the common data elements for traumatic brain injury.Journal of neurotrauma · 2013Trial
- A benchmark of text embedding models for semantic harmonization of Alzheimer's disease cohorts.The journal of prevention of Alzheimer's disease · 2025Article
- Semantic Harmonization of Alzheimer's Disease Datasets Using AD-Mapper.Journal of Alzheimer's disease : JAD · 2024Article
- Health data space nodes for privacy-preserving linkage of medical data to support collaborative secondary analyses.Frontiers in medicine · 2024Article
- The European medical information framework: A novel ecosystem for sharing healthcare data across Europe.Learning health systems · 2020Article
- Mining multi-site clinical data to develop machine learning MRI biomarkers: application to neonatal hypoxic ischemic encephalopathy.Journal of translational medicine · 2019Article
- PlatformTM, a standards-based data custodianship platform for translational medicine research.Scientific data · 2019Article
- Data and knowledge management in translational research: implementation of the eTRIKS platform for the IMI OncoTrack consortium.BMC bioinformatics · 2019Article
- Risk stratification integrating genetic data for factor VIII inhibitor development in patients with severe hemophilia A.PloS one · 2019Article
- A late-binding, distributed, NoSQL warehouse for integrating patient data from clinical trials.Database : the journal of biological databases and curation · 2019Article
- Phelan-McDermid syndrome data network: Integrating patient reported outcomes with clinical notes and curated genetic reports.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- A systems approach to renal inflammation in SLE.Clinical immunology (Orlando, Fla.) · 2017Review
- Secondary Use and Analysis of Big Data Collected for Patient Care.Yearbook of medical informatics · 2017Review
- Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned.Briefings in bioinformatics · 2017Article
- Semantic Health Knowledge Graph: Semantic Integration of Heterogeneous Medical Knowledge and Services.BioMed research international · 2017Article
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- Clinical Decision Support: a 25 Year Retrospective and a 25 Year Vision.Yearbook of medical informatics · 2016Review
- MOLGENIS/connect: a system for semi-automatic integration of heterogeneous phenotype data with applications in biobanks.Bioinformatics (Oxford, England) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe growing consensus that most valuable data source for biomedical discoveries is derived from human samples is clearly reflected in the growing number of translational medicine and translational sciences departments across pharma as well as academic and government supported initiatives such as Clinical and Translational Science Awards (CTSA) in the US and the Seventh Framework Programme (FP7) of EU with emphasis on translating research for human health.
methodsThe pharmaceutical companies of Johnson and Johnson have established translational and biomarker departments and implemented an effective knowledge management framework including building a data warehouse and the associated data mining applications. The implemented resource is built from open source systems such as i2b2 and GenePattern.
resultsThe system has been deployed across multiple therapeutic areas within the pharmaceutical companies of Johnson and Johnsons and being used actively to integrate and mine internal and public data to support drug discovery and development decisions such as indication selection and trial design in a translational medicine setting. Our results show that the established system allows scientist to quickly re-validate hypotheses or generate new ones with the use of an intuitive graphical interface.
conclusionsThe implemented resource can serve as the basis of precompetitive sharing and mining of studies involving samples from human subjects thus enhancing our understanding of human biology and pathophysiology and ultimately leading to more effective treatment of diseases which represent unmet medical needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.