ReviewCurrent molecular medicine2010
Understanding the role of aldose reductase in ocular inflammation.
Review in Current molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Anti-inflammatory mechanisms ofInternational journal of ophthalmology · 2026Article
- Naturally derived bioactive compounds as regulators of oxidative stress and inflammation in asthma.Chinese medicine · 2025Review
- The Role of Aldose Reductase in Polyol Pathway: An Emerging Pharmacological Target in Diabetic Complications and Associated Morbidities.Current pharmaceutical biotechnology · 2024Review
- Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation.Scientific reports · 2023Article
- Neuroprotective effect of aldose reductase knockout in a mouse model of spinal cord injury involves NF-κB pathway.Experimental brain research · 2022Article
- Sorbitol accumulation decreases oocyte quality in aged mice by altering the intracellular redox balance.Aging · 2021Article
- Aldose Reductase: a cause and a potential target for the treatment of diabetic complications.Archives of pharmacal research · 2021Review
- Aldose Reductase: An Emerging Target for Development of Interventions for Diabetic Cardiovascular Complications.Frontiers in endocrinology · 2021Review
- Nutraceutical effects ofAging · 2019Article
- Inhibition of ocular aldose reductase by a new benzofuroxane derivative ameliorates rat endotoxic uveitis.Mediators of inflammation · 2014Article
- 4-Hydroxynonenal in the pathogenesis and progression of human diseases.Current medicinal chemistry · 2014Review
- Aldose reductase from Schistosoma japonicum: crystallization and structure-based inhibitor screening for discovering antischistosomal lead compounds.Parasites & vectors · 2013Article
- Molecular cloning and characterization of Schistosoma japonicum aldose reductase.Parasitology research · 2013Article
- Deletion of aldose reductase from mice inhibits diabetes-induced retinal capillary degeneration and superoxide generation.PloS one · 2013Article
- Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats.Investigative ophthalmology & visual science · 2012Article
- A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases.Expert opinion on investigational drugs · 2012Review
- Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice.Investigative ophthalmology & visual science · 2011Article
- ALDOSE REDUCTASE: New Insights for an Old Enzyme.Biomolecular concepts · 2011Article
- Emerging role of antioxidants in the protection of uveitis complications.Current medicinal chemistry · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aldose reductase, although identified initially as a glucose-reducing enzyme via polyol pathway, is believed to be an important component of antioxidant defense system as well as a key mediator of oxidative stress-induced molecular signaling. The dual role played by AR has made it a very important enzyme for the regulation of not only the cellular redox state by detoxifying the reactive lipid-aldehydes generated by lipid peroxidation which is crucial in the cellular homeostasis, but also in the regulation of molecular signaling cascade that may regulate oxidative stress-induced cytotoxic events. Search for the new molecular targets to restrain the oxidative stress-induced inflammation has resulted in the identification of AR as an unanticipated mediator of oxidative stress-induced signaling. Although, in last one decade or so AR has been implicated in various inflammation-related diseases conditions ranging from diabetes, sepsis, cancer, cardiovascular and ocular inflammation, however, a critical evaluation of the clinical efficacy of AR inhibitors awaits a better understanding of the role of AR in regulating inflammation, especially in ocular inflammation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.