ArticleCellular and molecular life sciences : CMLS2011
Redundant and unique roles of coronin proteins in Dictyostelium.
Article in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Domain-selective folding of the tandem β-propeller protein Coronin 7 (Coro7) by the chaperonin CCT/TRiC.The Journal of biological chemistry · 2026Article
- Review
- Structural insights intoCurrent research in structural biology · 2021Article
- Interactome and F-Actin Interaction Analysis ofInternational journal of molecular sciences · 2020Article
- Emerging Functions of Actins and Actin Binding Proteins in Trypanosomatids.Frontiers in cell and developmental biology · 2020Review
- Review
- From Phagocytes to Immune Defense: Roles for Coronin Proteins inFrontiers in cellular and infection microbiology · 2018Review
- Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays.Journal of visualized experiments : JoVE · 2016Article
- Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins.Scientific reports · 2015Article
- A Simple Retroelement Based Knock-Down System in Dictyostelium: Further Insights into RNA Interference Mechanisms.PloS one · 2015Article
- Bleb-driven chemotaxis of Dictyostelium cells.The Journal of cell biology · 2014Article
- Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A.Molecular biology of the cell · 2014Article
- A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- On guard: coronin proteins in innate and adaptive immunity.Nature reviews. Immunology · 2013Review
- Article
- Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.The EMBO journal · 2011Article
- Unraveling the enigma: progress towards understanding the coronin family of actin regulators.Trends in cell biology · 2011Review
- Evolutionary crossroads in developmental biology: Dictyostelium discoideum.Development (Cambridge, England) · 2011Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dictyostelium discoideum harbors a short (CRN12) and a long coronin (CRN7) composed of one and two beta-propellers, respectively. They are primarily present in the cell cortex and cells lacking CRN12 (corA⁻) or CRN7 (corB⁻) have defects in actin driven processes. We compared the characteristics of a mutant cell line (corA⁻/corB⁻) lacking CRN12 and CRN7 with the single mutants focusing on cytokinesis, phagocytosis, chemotaxis and development. Cytokinesis, uptake of small particles, and developmental defects were not enhanced in the corA⁻/corB⁻ strain as compared to the single mutants, whereas motility and phagocytosis of yeast particles were more severely impaired. It appears that although both proteins affect the same processes they do not act in a redundant manner. Rather, they often act antagonistically, which is in accordance with their proposed roles in the actin cytoskeleton where CRN12 acts in actin disassembly whereas CRN7 stabilizes actin filaments and protects them from disassembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.