ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Up-regulation of histidine decarboxylase expression and histamine content in B16F10 murine melanoma cells.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Overexpression of histidine decarboxylase promotes cancer cell apoptosis and migration in HN5 cells.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Chronic Histamine Exposure Promotes Melanogenesis via ORAI1-STIM1-Mediated Calcium Signaling Remodeling.International journal of molecular sciences · 2026Article
- Article
- Histamine receptors and cancer pharmacology: an update.British journal of pharmacology · 2020Review
- Article
- Metabolomic study of serum from rabbits with acute acalculous cholecystitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system.Advances in anatomy, embryology, and cell biology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designThis study was conducted to determine if differences in histidine decarboxylase expression and histamine levels exist between B16F10 melanoma cells and non-cancerous Melan-A melanocytes.
methodsImmunofluorescence and western blot analysis were used to detect and compare histidine decarboxylase protein levels. Enzyme-linked immunoassay was used to detect, measure, and compare histamine levels.
resultsHistidine decarboxylase expression was found to be elevated in the B16F10 cells. Western blot analysis demonstrated levels of histidine decarboxylase protein expression more than twofold higher (p < 0.001) in B16F10 than in Melan-A cells. Histamine levels were 280-fold higher (p < 0.001) in B16F10 (229 ± 15 pg/mg protein) than in Melan-A (0.83 ± 0.03 pg/mg protein) cells.
conclusionResults indicate an up-regulated histaminergic system in the B16F10 melanoma cells when compared to non-cancerous melanocytes. This supports the use of B16F10 cells as a model in which to investigate a potential role of the endogenous histaminergic system in regulating malignant cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.